APPLICATION OF 2-SUBSTITUTED VINAMIDINIUM SALTS TO THE SYNTHESIS OF 2,4-DISUBSTITUTED PYRROLES

被引：89

作者：

GUPTON, JT ^{[1
]}

KROLIKOWSKI, DA ^{[1
]}

YU, RH ^{[1
]}

RIESINGER, SW ^{[1
]}

SIKORSKI, JA ^{[1
]}

机构：

[1] MONSANTO AGR CO,DIV TECHNOL,ST LOUIS,MO 63167

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1990年 / 55卷 / 15期

关键词：

D O I：

10.1021/jo00302a047

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A variety of 2-substituted vinamidinium salts react with a-amino acid esters under basic conditions to produce 2-carbethoxy-4-substituted-pyrroles in good yield. The overall process represents a short and efficient synthesis of highly functionalized pyrroles from a-substituted acetic acid precursors. Such reactions may involve the intermediacy of azomethine ylids or “pentadienyl like” anions. © 1990, American Chemical Society. All rights reserved.

引用

页码：4735 / 4740

页数：6

共 26 条

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