RECOVERY OF INTERBLOCK INFORMATION IN CROSS-OVER TRIALS

被引：7

作者：

CHI, EM

机构：

[1] Marion Merrell Dow, Cincinnati, Ohio, 45215

来源：

STATISTICS IN MEDICINE | 1991年 / 10卷 / 07期

关键词：

D O I：

10.1002/sim.4780100711

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

For cross-over designs, we show that one can recover information on direct and/or residual treatment effects from an inter-block (patients as blocks) analysis as is done in an incomplete block design1. By combining the intra- and inter-block estimates, we obtain the generalized least squares estimate. In analysing cross-over trials, we recommended this approach provided the between-patient variance component can be estimated efficiently.

引用

页码：1115 / 1122

页数：8

共 13 条

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