ISLET CELL AND THYROGASTRIC ANTIBODIES IN 633 CONSECUTIVE 15-YR-OLD TO 34-YR-OLD PATIENTS IN THE DIABETES INCIDENCE STUDY IN SWEDEN

被引:103
作者
LANDINOLSSON, M
KARLSSON, FA
LERNMARK, A
SUNDKVIST, G
ARNQVIST, H
BLOHME, G
LITHNER, F
LITTORIN, B
NYSTROM, L
ROSENQVIST, U
SCHERSTEN, B
WIBELL, L
OSTMAN, J
机构
[1] UNIV LUND,MALMO GEN HOSP,DEPT MED,S-21401 MALMO,SWEDEN
[2] LINKOPING UNIV,DEPT MED,S-58183 LINKOPING,SWEDEN
[3] SAHLGRENS UNIV HOSP,DEPT MED,S-41345 GOTHENBURG,SWEDEN
[4] UMEA UNIV,DEPT MED,S-90187 UMEA,SWEDEN
[5] DEPT COMMUNITY HLTH SCI,DALBY,SWEDEN
[6] UMEA UNIV,DEPT EPIDEMIOL & HLTH CARE RES,S-90187 UMEA,SWEDEN
[7] KAROLINSKA HOSP,DEPT SOCIAL SCI,S-10401 STOCKHOLM 60,SWEDEN
[8] KAROLINSKA INST,DEPT MED,S-14186 HUDDINGE,SWEDEN
[9] UNIV HOSP UPPSALA,DEPT MED,UPPSALA,SWEDEN
[10] UNIV WASHINGTON,DEPT MED,SEATTLE,WA 98195
关键词
D O I
10.2337/diabetes.41.8.1022
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The effect of age on ICA and thyrogastric antibodies at diagnosis of IDDM was evaluated in 633 consecutively diagnosed Swedish diabetic patients aged 15-34 yr and in 282 volunteers of the same age. ICAs were present in 61% (383 of 633) of the patients and in 2% (5 of 282) of control subjects. When the initial classification was considered, ICAs were detected in 69% (327 of 473) of patients with IDDM, 23% (19 of 83) of those with NIDDM, 50% (36 of 72) of those with unclassifiable diabetes, and 20% (1 of 5) of those with secondary diabetes. The frequency of ICA fell significantly (P < 0.001) with age in IDDM patients from 77% (104/135) in those 15-19 yr old to 52% (50 of 96) in 30- to 34-yr-old IDDM patients. The low frequency of ICA in 30- to 34-yr-old IDDM patients was confined to men (42%, 28 of 66). The frequency of gastric (H+, K+-ATPase) antibodies was significantly (P < 0.05) higher in IDDM patients (10%, 47 of 449) than in patients with NIDDM (3%, 3 of 80) and unclassifiable diabetes (4%, 3 of 72). In conclusion, the frequency of ICA at the diagnosis of IDDM in young adult subjects decreases with increasing age, particularly in men. The frequent finding of ICA in patients considered to have NIDDM or unclassifiable diabetes indicates that misclassification of diabetes is frequent in young adult patients recently diagnosed with diabetes.
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页码:1022 / 1027
页数:6
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