DEFECTIVE ASSOCIATION OF DYSTROPHIN WITH SARCOLEMMAL GLYCOPROTEINS IN THE CARDIOMYOPATHIC HAMSTER HEART

被引：57

作者：

IWATA, Y

NAKAMURA, H

MIZUNO, Y

YOSHIDA, M

OZAWA, E

SHIGEKAWA, M

机构：

[1] NATL CARDIOVASC CTR,RES INST,DEPT MOLEC PHYSIOL,SUITA,OSAKA 565,JAPAN

[2] NCNP,NATL INST NEUROSCI,DIV CELL BIOL,KODAIRA,TOKYO 187,JAPAN

来源：

FEBS LETTERS | 1993年 / 329卷 / 1-2期

关键词：

CARDIOMYOPATHY; CARDIOMYOPATHIC HAMSTER; DYSTROPHIN; DYSTROPHIN-ASSOCIATED GLYCOPROTEIN; MUSCULAR DYSTROPHY;

D O I：

10.1016/0014-5793(93)80227-L

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In ventricular muscle from 30- to 60-day-old Bio 14.6 cardiomyopathic hamsters, dystrophin-associated glycoproteins of 43, 50 and 150 kDa are markedly reduced in abundance. In particular, the 50-kDa glycoprotein is totally deficient in the sarcolemma of myopathic ventricular myocytes as revealed by immunofluorescence microscopy. The dystrophin-glycoprotein complex formation is defective in the cardiomyopathic hamster heart. because dystrophin and the glycoproteins behave independently when digitonin-solubilized ventricular homogenates are fractionated on wheat germ agglutinin beads or anti-dystrophin immunoaffinity beads.

引用

页码：227 / 231

页数：5

共 20 条

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