GRANULOMATOUS REACTION AND TISSUE REMODELING IN THE CUTANEOUS LESION OF CHROMOMYCOSIS

被引：37

作者：

ESTERRE, P

PEYROL, S

SAINTEMARIE, D

PRADINAUD, R

GRIMAUD, JA

机构：

[1] INST PASTEUR LYON,CNRS,URA 1459,UNITE PHYSIOPATHOL FIBROSES TISSULAIRES,AVE TONY GARNIER,F-69365 LYON O7,FRANCE

[2] HOP JEAN MARTIAL,INST PASTEUR GUYANE,PARASITOL LAB,CAYENNE,FRENCH GUIANA

[3] HOP JEAN MARTIAL,DEPT DERMATOL,CAYENNE,FRENCH GUIANA

来源：

VIRCHOWS ARCHIV A-PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY | 1993年 / 422卷 / 04期

关键词：

CHROMOMYCOSIS; SKIN; GRANULOMA; IMMUNOHISTOCHEMISTRY; ELECTRON MICROSCOPY;

D O I：

10.1007/BF01608337

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

The cell-mediated immune reaction was studied in the cutaneous lesion of chromomycosis, using monoclonal antibodies against polymorphonuclear neutrophils, macrophage and lymphocyte subsets, endothelial and fibroblast cells. In addition, immunostaining of the main degradative enzymes (neutrophil elastase and interstitial collagenase) and certain important cytokines (transforming growth factor-beta, tumour necrosis factor-alpha and interferon-gamma) suggested an explanation for the granulomatous reaction and the associated tissue remodelling. The distribution pattern of neutrophils and macrophage subsets, observed by computer-aided image analysis, suggests that the in situ persistence of fungi is the main pathological factor.

引用

页码：285 / 291

页数：7

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ESTERRE, P ;

PEYROL, S ;

GUERRET, S ;

SAINTEMARIE, D ;

PRADINAUD, R ;

GRIMAUD, JA .

PATHOLOGY RESEARCH AND PRACTICE, 1992, 188 (07) :894-900

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