ANALYSIS OF THE PHASE-SHIFTING EFFECTS OF GASTRIN-RELEASING PEPTIDE WHEN MICROINJECTED INTO THE SUPRACHIASMATIC REGION

被引：27

作者：

ALBERS, HE ^{[1
]}

GILLESPIE, CF ^{[1
]}

BABAGBEMI, TO ^{[1
]}

HUHMAN, KL ^{[1
]}

机构：

[1] GEORGIA STATE UNIV,DEPT PSYCHOL,ATLANTA,GA 30303

来源：

NEUROSCIENCE LETTERS | 1995年 / 191卷 / 1-2期

关键词：

CIRCADIAN; SUPRACHIASMATIC; GASTRIN RELEASING PEPTIDE; VASOACTIVE INTESTINAL PEPTIDE; PEPTIDE HISTIDINE ISOLEUCINE;

D O I：

10.1016/0304-3940(95)11559-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The role of gastrin releasing peptide (GRP) in phase shifting circadian rhythms was investigated. Microinjection of GRP into the suprachiasmatic region (SCN) region produced only small changes in the phase of free-running circadian activity rhythms in hamsters housed in constant darkness. However, co-administration of GRP with vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI) produced significantly larger phase delays than GRP alone. These data support the hypothesis that GRP interacts with VIP and PHI within the SCN to induce phase shifts of circadian rhythms.

引用

页码：63 / 66

页数：4

共 21 条

[1]

ALBERS HE, 1992, PROG BRAIN RES, V92, P289

[2]

ALBERS HE, 1991, J NEUROSCI, V11, P846

[3] NEUROPEPTIDE-Y - ROLE IN LIGHT DARK CYCLE ENTRAINMENT OF HAMSTER CIRCADIAN-RHYTHMS [J].