SUBACUTE SCLEROSING PANENCEPHALITIS - PROPAGATION OF MEASLES VIRUS FROM BRAIN BIOPSY IN TISSUE CULTURE

被引：156

作者：

CHEN, TT

WATANABE, I

ZEMAN, W

MEALEY, J

机构：

[1] Division of Neurosurgery, Indiana University Medical Center, Indianapolis

来源：

SCIENCE | 1969年 / 163卷 / 3872期

关键词：

D O I：

10.1126/science.163.3872.1193

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Measles virus was propagated in monolayer cultures established from brain tissue of a patient with subacute sclerosing panencephalitis. Syncytial cells were rendered fluorescent with measles specific antiserums only, by means of an indirect technique. The ultrastructural appearance of the microtubular aggregates was identical in brain tissue and in the cultured cells. Fusion experiments produced a cytopathic effect in human embryonic kidney and VERO cell cultures. The virus was identified by hemagglutination-inhibition, but only in the supernatant of disrupted cultured cells.

引用

页码：1193 / &

共 11 条

[1]

Bouteille M, 1965, REV NEUROL, V118, P454

[2]

BUABLIS JV, 1968, P SOC EXP BIOL, V129, P593

[3]

CONNOLLY JH, 1967, LANCET, V1, P542

[4] Cellular inclusions in cerebral lesions of epidemic encephalitis - Second report [J].