EFFECTS OF IONS ON THE BINDING OF AGONISTS AND ANTAGONISTS TO MUSCARINIC RECEPTORS

被引：74

作者：

BIRDSALL, NJM

BURGEN, ASV

HULME, EC

WELLS, JW

机构：

[1] Division of Molecular Pharmacology, National Institute for Medical Research, London

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 1979年 / 67卷 / 03期

关键词：

D O I：

10.1111/j.1476-5381.1979.tb08690.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

There are no selective effects of Na+, K+, Ca2+, Mg2+ or Cl− on the binding of antagonists or agonists to muscarinic receptors in rat brain. A decrease in affinity related to ionic strength is found for all these ions. Larger effects were produced by T+, La3+, and some transition metal ions. 1979 British Pharmacological Society

引用

页码：371 / 377

页数：7

共 28 条

[1] LIFE TIME AND ELEMENTARY CONDUCTANCE OF CHANNELS MEDIATING EXCITATORY EFFECTS OF ACETYLCHOLINE IN APLYSIA NEURONS
ASCHER, P
MARTY, A
NEILD, TO
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 1978, 278 (MAY): : 177 - 206
[2] Birdsall N.J. M., 1976, OPIATES ENDOGENOUS O, P19
[3] BIRDSALL NJM, 1978, MOL PHARMACOL, V14, P723
[4] BIRDSALL NJM, 1977, BRIT J PHARMACOL, V59, pP503
[5] BIRDSALL NJM, 1978, CHOLINERGIC MECHANIS
[6] BIRNBAUMER L, 1977, CYCLIC 3 5 NUCLEOTID, P13
[7] DYNAMIC PROPERTIES OF ISOLATED ACETYLCHOLINE-RECEPTOR PROTEINS - RELEASE OF CALCIUM-IONS CAUSED BY ACETYLCHOLINE BINDING
CHANG, HW
NEUMANN, E
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1976, 73 (10) : 3364 - 3368
[8] MECHANISMS OF DRUG ACTION AT VOLUNTARY MUSCLE ENDPLATE
COLQUHOUN, D
[J]. ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 1975, 15 : 307 - 325
[9] EFFECTS OF INTRACELLULAR POTASSIUM + SODIUM INJECTIONS ON INHIBITORY POSTSYNAPTIC POTENTIAL
ECCLES, J
ECCLES, RM
ITO, M
[J]. PROCEEDINGS OF THE ROYAL SOCIETY SERIES B-BIOLOGICAL SCIENCES, 1964, 160 (979): : 181 - +
[10] FUNCTIONAL ACETYLCHOLINE RECEPTOR-ELECTROPLAX MEMBRANE MICROSACS (VESICLES) - PURIFICATION AND CHARACTERIZATION
HESS, GP
ANDREWS, JP
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (02) : 482 - 486

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