EVIDENCES FOR THE EXISTENCE OF ENDOTHELIUM-DERIVED RELAXING FACTOR IN THE RENAL MEDULLA

被引：43

作者：

BIONDI, ML ^{[1
]}

DOUSA, T ^{[1
]}

VANHOUTTE, P ^{[1
]}

ROMERO, JC ^{[1
]}

机构：

[1] MAYO CLIN & MAYO FDN,MAYO SCH MED,DEPT PHYSIOL & BIOPHYS,ROCHESTER,MN 55905

来源：

AMERICAN JOURNAL OF HYPERTENSION | 1990年 / 3卷 / 11期

关键词：

CGMP; acetylcholine; Endothelium-derived relaxing factor; Renal medulla;

D O I：

10.1093/ajh/3.11.876

中图分类号：

R6 [外科学];

学科分类号：

1002 ; 100210 ;

摘要：

The basal levels of cGMP in renal medulla slices were enhanced when the slices were stimulated with both endothelium-dependent (acetylcholine) and endothelium-independent (molsidomine) vasodilators. When preincubated with NG-mono-methyl-L-arginine, a specific inhibitor of endothe-lium-derived relaxing factor, only the acetycholine-stimulated increase was completely abolished. Furthermore, a preincubation with L-arginine, a selective precursor of endothelium-derived relaxing factor, enhanced the cGMP levels. The results indicate that the renal medulla, presumably the endothelial cells of the vasa recta, is able to produce endothelium-derived relaxing factor. © 1990 by the American Journal of Hypertension, Ltd.

引用

页码：876 / 878

页数：3

共 18 条

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