PHARMACOLOGICAL DIFFERENTIATION BETWEEN THE CHEMOTACTIC FACTOR INDUCED INTRACELLULAR CALCIUM REDISTRIBUTION AND TRANSMEMBRANE CALCIUM INFLUX IN RABBIT NEUTROPHILS

被引：49

作者：

NACCACHE, PH ^{[1
]}

SHOWELL, HJ ^{[1
]}

BECKER, EL ^{[1
]}

SHAAFI, RI ^{[1
]}

机构：

[1] UNIV CONNECTICUT, CTR HLTH, DEPT PATHOL, FARMINGTON, CT 06032 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 89卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0006-291X(79)92139-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nordihydroguaiaretic acid selectively inhibited the chemotactic factor induced stimulation of Ca influx and increase in the steady-state level of cell-associated 45Ca observed in the presence of Ca in rabbit peritoneal neutrophils. Nordihydroguaiaretic acid did not inhibit the transient decreases in the steady state levels of 45Ca observed in the presence of low extracellular Ca or of low concentrations of chemotactic factors. Nordihydroguaiaretic acid apparently does not affect the intracellular Ca redistribution induced by chemotactic factors but rather inhibits the influx of extracellular Ca which accompanies stimulation.

引用

页码：1224 / 1230

页数：7

共 15 条

[1] BECKER EL, 1972, Z IMMUNITATSFORSCH, V143, P466
[2] ARACHIDONIC-ACID METABOLISM IN POLYMORPHONUCLEAR LEUKOCYTES .3. EFFECTS OF IONOPHORE-A23187
BORGEAT, P
SAMUELSSON, B
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1979, 76 (05) : 2148 - 2152
[3] GOETZL EJ, 1979, FED PROC, V38, P1085
[4] HANBERG M, 1976, BIOCHIM BIOPHYS ACTA, V431, P651
[5] Michell R H, 1977, Adv Exp Med Biol, V83, P447
[6] TRANSPORT OF SODIUM, POTASSIUM, AND CALCIUM ACROSS RABBIT POLYMORPHONUCLEAR LEUKOCYTE MEMBRANES - EFFECT OF CHEMOTACTIC FACTOR
NACCACHE, PH
SHOWELL, HJ
BECKER, EL
SHAAFI, RI
[J]. JOURNAL OF CELL BIOLOGY, 1977, 73 (02) : 428 - 444
[7] CHEMOTACTIC FACTOR-INDUCED RELEASE OF MEMBRANE CALCIUM IN RABBIT NEUTROPHILS
NACCACHE, PH
VOLPI, M
SHOWELL, HJ
BECKER, EL
SHAAFI, RI
[J]. SCIENCE, 1979, 203 (4379) : 461 - 463
[8] CHANGES IN IONIC MOVEMENTS ACROSS RABBIT POLYMORPHONUCLEAR LEUKOCYTE MEMBRANES DURING LYSOSOMAL ENZYME-RELEASE - POSSIBLE IONIC BASIS FOR LYSOSOMAL ENZYME-RELEASE
NACCACHE, PH
SHOWELL, HJ
BECKER, EL
SHAAFI, RI
[J]. JOURNAL OF CELL BIOLOGY, 1977, 75 (03) : 635 - 649
[9] RAPID STIMULATION OF PROTEIN CARBOXYMETHYLATION IN LEUKOCYTES BY A CHEMOTACTIC PEPTIDE
ODEA, RF
VIVEROS, OH
AXELROD, J
ASWANKUMAR, S
SCHIFFMANN, E
CORCORAN, BA
[J]. NATURE, 1978, 272 (5652) : 462 - 464
[10] OFLAHERTY JT, 1977, J IMMUNOL, V119, P232

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