PLASMA COCAETHYLENE CONCENTRATIONS IN PATIENTS TREATED IN THE EMERGENCY ROOM OR TRAUMA UNIT

被引:53
作者
BAILEY, DN
机构
[1] Department of Pathology, California University Medical Center, San Diego, CA 92103-8320
关键词
BENZOYLECGONINE; COCAETHYLENE; COCAINE; EMERGENCY ROOM; PLASMA CONCENTRATIONS; TRAUMA;
D O I
10.1093/ajcp/99.2.123
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Cocaethylene and cocaine concentrations were measured by high-pressure liquid chromatography in the plasma of 18 patients whose corresponding blood demonstrated ethanol and whose urine contained either benzoylecgonine and/or cocaine on screening for illicit drug use. Although sixteen patients had suffered trauma, only 15 were admitted to the trauma unit. Three patients were seen only in the emergency room. Both cocaethylene and cocaine were detected together in the plasma of 10 patients and not at all in 5 patients. In two patients, cocaine was found without cocaethylene, and in one patient cocaethylene was present without cocaine. For the entire series, cocaine concentrations showed significant correlation with those of cocaethylene. Plasma cocaethylene concentrations varied and were as high as 784 nmol/L (249 mug/L), and those of cocaine were as high as 1,455 nmol/L (441 mug/L). Before this study, published measurements of cocaethylene have been limited almost exclusively to postmortem specimens.
引用
收藏
页码:123 / 127
页数:5
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