AZO POLYMERS FOR COLON-SPECIFIC DRUG DELIVERY

被引：75

作者：

VANDENMOOTER, G ^{[1
]}

SAMYN, C ^{[1
]}

KINGET, R ^{[1
]}

机构：

[1] KU LEUVEN,MACROMOLEC FYS ORGAN CHEM LAB,LOUVAIN,BELGIUM

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1992年 / 87卷 / 1-3期

关键词：

COLON TARGETING; AZO POLYMER; AZO REDUCTION; BIODEGRADABLE COATING; PERMEABILITY; SELECTIVE DRUG DELIVERY;

D O I：

10.1016/0378-5173(92)90225-Q

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In order to develop a colon-specific drug delivery system, copolymers of 2-hydroxyethyl methacrylate and methyl methacrylate were prepared in the presence of bis(methacryloylamino)azobenzene. The conditions of polymerization were optimized to prevent crosslinking. Film coatings were prepared with the azo polymers. The films were insoluble in simulated gastric and intestinal juice. Dependent on the content of the hydrophilic groups in the polymers, the films were more or less permeable to water. In vitro and in vivo tests prove that it is possible to use the polymers to deliver drugs to the large intestine. Due to the presence of the azo compound, the azo polymer coatings can be degraded by intestinal bacteria.

引用

页码：37 / 46

页数：10

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