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DESFERRIOXAMINE TREATMENT REDUCES HISTOLOGICAL EVIDENCE OF LUNG DAMAGE IN RATS AFTER ACUTE NITROGEN-DIOXIDE (NO2) INTOXICATION

被引：7
作者：
MEULENBELT, J
DORMANS, JAMA
VANBREE, L
ROMBOUT, PJA
SANGSTER, B
机构：
[1] NATL INST PUBL HLTH & ENVIRONM PROTECT,PATHOL LAB,3720 BA BILTHOVEN,NETHERLANDS
[2] NATL INST PUBL HLTH & ENVIRONM PROTECT,TOXICOL LAB,3720 BA BILTHOVEN,NETHERLANDS
[3] UNIV UTRECHT HOSP,DEPT INTENS CARE & CLIN TOXICOL,3511 GV UTRECHT,NETHERLANDS
来源：
HUMAN & EXPERIMENTAL TOXICOLOGY | 1993年 / 12卷 / 05期
关键词：
D O I：
10.1177/096032719301200508
中图分类号：
R99 [毒物学（毒理学）];
学科分类号：
100405 ;
摘要：
1 In previous studies a rat inhalation model was developed to investigate the efficacy of treatment in acute NO2 intoxication. 2 Desferrioxamine was administered intravenously to study its effect on histological alterations in lung tissue in rats after acute NO2 exposure. 3 Twenty four hours after exposure to 175 ppm NO2 for 10 minutes the lung injury observed by light microscopy in the desferrioxamine treated rats was less pronounced than in the saline treated rats. 4 Desferrioxamine appeared to provide more protection with a dose of 1 00 mg kg-1 24 h-1 than with 200 mg kg-1 24 h-1.
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收藏
页码：389 / 395
页数：7
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