PHYSICOCHEMICAL PROPERTIES OF 2-METHYLTHIO-4-METHYLPHENOL, A MODEL-COMPOUND OF THE NOVEL COFACTOR OF GALACTOSE-OXIDASE

被引：34

作者：

ITOH, S

HIRANO, K

FURUTA, A

KOMATSU, M

OHSHIRO, Y

ISHIDA, A

TAKAMUKU, S

KOHZUMA, T

NAKAMURA, N

SUZUKI, S

机构：

[1] OSAKA UNIV, INST SCI & IND RES, IBARAKI, OSAKA 567, JAPAN

[2] OSAKA UNIV, COLL GEN EDUC, INST CHEM, TOYONAKA, OSAKA 560, JAPAN

来源：

CHEMISTRY LETTERS | 1993年 / 12期

关键词：

D O I：

10.1246/cl.1993.2099

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Physicochemical properties of 2-methylthio-4-methylphenol (1) were examined in order to obtain information about the nature of the newly found cofactor of galactose oxidase. Electrochemical studies and theoretical calculations indicated that the methylthio group works as an electron-withdrawing substituent to stabilize the radical species (one-electron oxidation state) of 1. The absorption spectrum obtained by the pulse radiolysis of 1 was very close to that of the oxidized apoenzyme.

引用

页码：2099 / 2102

页数：4

共 17 条

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