TWIN GENES AND ENDOCRINE DISEASE - CYP21 AND CYP11B GENES

被引：18

作者：

HELMBERG, A ^{[1
]}

机构：

[1] UNIV INNSBRUCK, SCH MED, INST GEN & EXPTL PATHOL, DEPT MOLEC BIOL, A-6020 INNSBRUCK, AUSTRIA

来源：

ACTA ENDOCRINOLOGICA | 1993年 / 129卷 / 02期

关键词：

D O I：

10.1530/acta.0.1290097

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

CYP21 and CYP11B genes have a common feature: they are ''twin'' genes. It seems as if doubling and subsequent drifting apart rendered these genes particularly sensitive to defect acquisition by mechanisms involving recombinatorial events. This creates specific difficulties in the molecular diagnosis of defects.

引用

页码：97 / 108

页数：12

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