CIRCULATING IMMUNE-COMPLEXES IN SERA FROM PATIENTS RECEIVING PROCAINAMIDE

被引：19

作者：

BECKER, M

KLAJMAN, A

MOALEM, T

YARETZKY, A

BENEFRAIM, S

机构：

[1] MEIR HOSP,MED DEPT B,KFAR SABA,ISRAEL

[2] TEL AVIV UNIV,SACKLER SCH MED,RAMAT AVIV,ISRAEL

来源：

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY | 1979年 / 12卷 / 02期

关键词：

D O I：

10.1016/0090-1229(79)90010-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Sera from patients receiving procainamide (PrA) therapy were investigated for their ability to inhibit an antibody-dependent cell-mediated cytotoxicity system (ADCC). Before the start of therapy 1 out of 20 sera from patients were inhibitory. Two months following the onset of therapy, 21 out of 29 sera (72%) inhibited ADCC. Sera from 13 out of 29 (44%) patients receiving PrA for periods greater than 6 months still displayed inhibitory factors. The inhibitory factors were found by sucrose-gradient ultracentrifugation to be located mainly in fractions 7 S to 19 S. Adsorption of sera with anti-human IgG linked to Sepharose removed inhibitory factors whereas similar treatment with anti-human IgM Sepharose did not, indicating that IgG was present in the inhibitory material. These results are consistent with the hypothesis that PrA induces IgG-containing immune complexes. © 1979.

引用

页码：220 / 227

页数：8

共 16 条

[1] BECKER MH, UNPUBLISHED
[2] BOYUM A, 1968, SCAND J CLIN LAB INV, VS 21, P77
[3] COLTON T, 1974, STATISTICS MEDICINE
[4] DUBOIS EL, 1969, MEDICINE, V48, P217
[5] FARRELL C, 1977, SCAND J IMMUNOL, V6, P1233
[6] ANTIBODY-DEPENDENT CELL-MEDIATED CYTOTOXICITY IN SELECTED AUTOIMMUNE-DISEASES
FELDMANN, JL
BECKER, MJ
MOUTSOPOULOS, H
FYE, K
BLACKMAN, M
EPSTEIN, WV
TALAL, N
[J]. JOURNAL OF CLINICAL INVESTIGATION, 1976, 58 (01) : 173 - 179
[7] EXPERIMENTAL STUDIES ON MECHANISM OF INDUCTION OF ANTI-NUCLEAR ANTIBODIES BY PROCAINAMIDE
GOLD, EF
BENEFRAIM, S
FAIVISEWITZ, A
STEINER, Z
KLAJMAN, A
[J]. CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1977, 7 (02): : 176 - 186
[8] KLAJMAN A, 1972, INT ARCH ALLER A IMM, V43, P630
[9] PROCAINAMIDE-INDUCED ANTIBODIES TO NUCLEOPROTEIN, DENATURED AND NATIVE DNA IN HUMAN SUBJECTS
KLAJMAN, A
FARKAS, R
GOLD, E
BENEFRAIM, S
[J]. CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY, 1975, 3 (04): : 525 - 530
[10] CIRCULATING IMMUNE-COMPLEXES IN STEROID-RESPONSIVE NEPHROTIC SYNDROME
LEVINSKY, RJ
MALLESON, PN
BARRATT, TM
SOOTHILL, JF
[J]. NEW ENGLAND JOURNAL OF MEDICINE, 1978, 298 (03) : 126 - 129

← 1 2 →