BIAS IN THE ONE-STEP METHOD FOR POOLING STUDY RESULTS

被引：104

作者：

GREENLAND, S

SALVAN, A

机构：

[1] Department of Epidemiology, UCLA School of Public Health, Los Angeles, California

来源：

STATISTICS IN MEDICINE | 1990年 / 9卷 / 03期

关键词：

D O I：

10.1002/sim.4780090307

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The one‐step (Peto) method for obtaining pooled effect estimates can yield extremely biased results when applied to unbalanced data. Even for balanced studies, the one‐step estimate may incorporate an unacceptable degree of bias. In place of the one‐step estimate, we recommend use of ordinary Mantel‐Haenszel, weighted least squares, or maximum likelihood estimates whenever the total number of events is adequate for such methods. If the total number of events is small, we recommend exact methods. Copyright © 1990 John Wiley & Sons, Ltd.

引用

页码：247 / 252

页数：6

共 13 条

[1] Berlin J.A., Laird N.M., Sacks H.S., Chalmers T.C., A comparison of statistical methods for combining event rates from clinical trials, Statistics in Medicine, 8, pp. 141-151, (1989)
[2] DerSimonian R., Laird N.M., Meta‐analysis in clinical trials, Controlled Clinical Trials, 7, pp. 177-188, (1988)
[3] Yusuf S., Peto R., Lewis J., Collins R., Sleight P., Beta blockade during and after myocardial infarction: an overview of the randomized trials, Progress in Cardiovascular Diseases, 27, pp. 335-371, (1985)
[4] Greenland S., Quantitative methods in the review of epidemiologic literature, Epidemiologic Reviews, 9, pp. 1-30, (1987)
[5] Risch H.A., A unified framework for meta‐analysis by maximum likelihood, American Journal of Epidemiology, 128, (1988)
[6] McCullagh P., Nelder J.A., Generalized Linear Models, (1983)
[7] Fleiss J.A., Statistical Methods for Rates and Proportions, (1981)
[8] Rothman K.J., Modern Epidemiology, (1986)
[9] Robins J.M., Greenland S., Breslow N.E., A general estimator for the variance of the Mantel‐Haenszel odds ratio, American Journal of Epidemiology, 124, pp. 719-723, (1986)
[10] Guilbaud O., On the large‐sample distribution of the Mantel‐Haenszel odds‐ratio estimator, Biometrics, 39, pp. 523-525, (1983)

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