IMMUNODEFICIENT MICE RECOVER FROM INFECTION WITH VACCINIA VIRUS EXPRESSING INTERFERON-GAMMA

被引：118

作者：

KOHONENCORISH, MRJ ^{[1
]}

KING, NJC ^{[1
]}

WOODHAMS, CE ^{[1
]}

RAMSHAW, IA ^{[1
]}

机构：

[1] UNIV SYDNEY,DEPT ANAT,SYDNEY,NSW 2006,AUSTRALIA

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1990年 / 20卷 / 01期

关键词：

D O I：

10.1002/eji.1830200123

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recombinant vaccinia viruses (VV)‐encoding murine interferon‐γ (IFN‐γ) were constructed and the effect of virus‐encoded IFN‐γ on the immune response towards VV in vivo investigated. In athymic nude mice and sublethally irradiated euthymic mice, IFN‐γ expression by VV enabled the mice to recover from the infection, whereas mice infected with the control virus died. In normal CBA/H mice also, the growth of VV was greatly reduced and it was cleared faster from mouse organs than the control virus. Natural killer (NK) cell responses in these mice were not enhanced suggesting that this recovery is not NK cell mediated. Other possible mechanisms and implications of this observation are discussed. Copyright © 1990 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim

引用

页码：157 / 161

页数：5

共 28 条

[1] VACCINIA VIRUS RECOMBINANTS EXPRESSING THE SA11-ROTAVIRUS VP7-GLYCOPROTEIN GENE INDUCE SEROTYPE-SPECIFIC NEUTRALIZING ANTIBODIES
ANDREW, ME
BOYLE, DB
COUPAR, BEH
WHITFELD, PL
BOTH, GW
BELLAMY, AR
[J]. JOURNAL OF VIROLOGY, 1987, 61 (04) : 1054 - 1060
[2] EFFECT OF GAMMA-INTERFERON ON CACHECTIN EXPRESSION BY MONONUCLEAR PHAGOCYTES - REVERSAL OF THE LPSD (ENDOTOXIN RESISTANCE) PHENOTYPE
BEUTLER, B
TKACENKO, V
MILSARK, I
KROCHIN, N
CERAMI, A
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1986, 164 (05) : 1791 - 1796
[3] MECHANISMS OF RECOVERY FROM A GENERALIZED VIRAL INFECTION - MOUSEPOX .1. EFFECTS OF ANTI-THYMOCYTE SERUM
BLANDEN, RV
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1970, 132 (05) : 1035 - &
[4] MULTIPLE-CLONING-SITE PLASMIDS FOR THE RAPID CONSTRUCTION OF RECOMBINANT POXVIRUSES
BOYLE, DB
COUPAR, BEH
BOTH, GW
[J]. GENE, 1985, 35 (1-2) : 169 - 177
[5] GAMMA-INTERFERON ENHANCES MACROPHAGE TRANSCRIPTION OF THE TUMOR-NECROSIS-FACTOR CACHECTIN, INTERLEUKIN-1, AND UROKINASE GENES, WHICH ARE CONTROLLED BY SHORT-LIVED REPRESSORS
COLLART, MA
BELIN, D
VASSALLI, JD
DEKOSSODO, S
VASSALLI, P
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1986, 164 (06) : 2113 - 2118
[6] EFFECT OF INVITRO MUTATIONS IN A VACCINIA VIRUS EARLY PROMOTER REGION MONITORED BY HERPES-SIMPLEX VIRUS THYMIDINE KINASE EXPRESSION IN RECOMBINANT VACCINIA VIRUS
COUPAR, BEH
BOYLE, DB
BOTH, GW
[J]. JOURNAL OF GENERAL VIROLOGY, 1987, 68 : 2299 - 2309
[7] HUMAN GAMMA INTERFERON AND TUMOR NECROSIS FACTOR EXERT A SYNERGISTIC BLOCKADE ON THE REPLICATION OF HERPES-SIMPLEX VIRUS
FEDUCHI, E
ALONSO, MA
CARRASCO, L
[J]. JOURNAL OF VIROLOGY, 1989, 63 (03) : 1354 - 1359
[8] CLONING AND EXPRESSION OF MURINE IMMUNE INTERFERON CDNA
GRAY, PW
GOEDDEL, DV
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (19): : 5842 - 5846
[9] IMMUNE SPECIFIC INDUCTION OF INTERFERON PRODUCTION IN CULTURES OF HUMAN BLOOD LYMPHOCYTES
GREEN, JA
COOPERBA.SR
KIBRICK, S
[J]. SCIENCE, 1969, 164 (3886) : 1415 - &
[10] CELLULAR IMMUNITY IN VACCINIA INFECTION OF MICE - ANTI-THYMOCYTE SERUM EFFECTS ON PRIMARY AND SECONDARY RESPONSIVENESS
HIRSCH, MS
NAHMIAS, AJ
MURPHY, FA
KRAMER, JH
[J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1968, 128 (01) : 121 - &

← 1 2 3 →