ENANTIOMERIC RESOLUTION OF DNS-AMINO ACIDS BY LIGAND-EXCHANGE CHROMATOGRAPHY - COMPARISON OF DIFFERENT CHIRAL AMINO-ACID AMIDES AS ADDITIVES TO THE MOBILE PHASE

被引：4

作者：

GIRELLI, AM ^{[1
]}

SINIBALDI, M ^{[1
]}

机构：

[1] CNR,IST CROMATOG,ROME,ITALY

来源：

CHIRALITY | 1990年 / 2卷 / 03期

关键词：

bis(L‐amino acid amidato)–copper(II) complexes; HPLC;

D O I：

10.1002/chir.530020311

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A study developing enantiomeric separations by metal chelate additives to the mobile phase in reversed‐phase liquid chromatography is reported. In particular the use of Cu(II) complexes of L‐prolinamide (L‐ProNH2) and L‐valinamide (L‐ValNH2) is examined and discussed. Interestingly, for a series of DNS‐amino acids these selectors show higher enantioselectivity than that obtained with the corresponding nonderivatized amino acid–Cu(II) complexes. Copyright © 1990 Wiley‐Liss, Inc.

引用

页码：190 / 193

页数：4

共 9 条

[1] HIGH-PERFORMANCE LIGAND-EXCHANGE CHROMATOGRAPHY OF AMINO-ACIDS ON CHIRAL STATIONARY PHASES [J].