SUBSENSITIVITY OF THE NOREPINEPHRINE RECEPTOR-COUPLED ADENYLATE-CYCLASE SYSTEM IN BRAIN - EFFECTS OF NISOXETINE VERSUS FLUOXETINE

被引：60

作者：

MISHRA, R ^{[1
]}

JANOWSKY, A ^{[1
]}

SULSER, F ^{[1
]}

机构：

[1] TENNESSEE NEUROPSYCHIAT INST,NASHVILLE,TN 37232

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1979年 / 60卷 / 04期

关键词：

!sup]3[!/sup]H-Dihydroalprenolol binding; Cyclic AMP; Fluoxetine; NE receptors; Nisoxetine; Subsensitivity;

D O I：

10.1016/0014-2999(79)90246-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Chronic administration of the norepinephrine (NE) reuptake inhibitor nisoxetine reduced the sensitivity of the NE receptor-coupled adenylate cyclase system in rat cortex. This subsensitivity, unlike that caused by desipramine (DMI), was not related to a reduction in specific β-adrenergic receptor binding. The specific serotonin reuptake inhibitor fluoxetine had no effect on either neurohormonal sensitivity or 3H-dihydroalprenolol binding. © 1979.

引用

页码：379 / 382

页数：4

共 10 条

[1] NORADRENERGIC CYCLIC-AMP GENERATING SYSTEM IN LIMBIC FOREBRAIN - PHARMACOLOGICAL CHARACTERIZATION INVITRO AND POSSIBLE ROLE OF LIMBIC NORADRENERGIC MECHANISMS IN MODE OF ACTION OF ANTIPSYCHOTICS
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[9] SCHMIDT MJ, 1977, ARCH INT PHARMACOD T, V229, P42
[10] FUNCTIONAL ASPECTS OF NOREPINEPHRINE RECEPTOR COUPLED ADENYLATE-CYCLASE SYSTEM IN LIMBIC FOREBRAIN AND ITS MODIFICATION BY DRUGS WHICH PRECIPITATE OR ALLEVIATE DEPRESSION - MOLECULAR APPROACHES TO AN UNDERSTANDING OF AFFECTIVE-DISORDERS
SULSER, F
[J]. PHARMAKOPSYCHIATRIE NEURO-PSYCHOPHARMAKOLOGIE, 1978, 11 (01): : 43 - 52

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