DIFFERENTIAL DISTRIBUTION OF CHICKEN-I AND CHICKEN-II GNRH IN THE TURTLE BRAIN

被引：28

作者：

TSAI, PS ^{[1
]}

LICHT, P ^{[1
]}

机构：

[1] UNIV CALIF BERKELEY,DEPT INTEGRAT BIOL,BERKELEY,CA 94720

来源：

PEPTIDES | 1993年 / 14卷 / 02期

基金：

美国国家科学基金会;

关键词：

DIFFERENTIAL DISTRIBUTION; TURTLE; CHICKEN GNRH; HPLC; GNRH RIA;

D O I：

10.1016/0196-9781(93)90033-D

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Chicken-I and chicken-II gonadotropin-releasing hormone (cI-GnRH and cII-GnRH) were shown to be differentially distributed in the brain of a turtle, Trachemys scripta, by HPLC and specific radioimmunoassays. The cI-GnRH was most concentrated in the median eminence (ME), while cII-GnRH was most concentrated in the caudal brain regions, especially medulla and cerebellum. The ratio of cI- to cII-GnRH in the ME of adults was 8: 1. Age- and sex-related differences in GnRH concentrations were observed exclusively in the ME: adult females had significantly higher cI-GnRH than younger females and adult males; adult females also had significantly higher cII-GnRH than hatchling females. Their differential distribution and sex- and age-related differences suggest that the two peptides may have distinct physiological roles, cI-GnRH is likely the form responsible for stimulating gonadotropin release.

引用

页码：221 / 226

页数：6

共 20 条

[1]

HASEGAWA Y, 1986, 10TH P ANN M JAP SOC, P7

[2] DIFFERENTIAL REGIONAL DISTRIBUTION AND RELEASE OF 2 FORMS OF GONADOTROPIN-RELEASING HORMONE IN THE CHICKEN BRAIN [J].

KATZ, IA ;

MILLAR, RP ;

KING, JA .

PEPTIDES, 1990, 11 (03) :443-450

[3] IDENTIFICATION OF HIS5, TRP7, TYR8-GNRH (CHICKEN GNRH-II) IN AMPHIBIAN BRAIN [J].

KING, JA ;

MILLAR, RP .

PEPTIDES, 1986, 7 (05) :827-834

[4]

KING JA, 1990, PROG CLIN BIOL RES, V342, P54

[5]

LICHT P, 1985, GEN COMP ENDOCR, V59, P442

[6] LOCALIZATION OF AVIAN LHRH-IMMUNOREACTIVE NEURONS IN THE HYPOTHALAMUS OF THE DOMESTIC-FOWL, GALLUS-DOMESTICUS, AND THE JAPANESE QUAIL, COTURNIX-COTURNIX [J].

MIKAMI, S ;

YAMADA, S ;

HASEGAWA, Y ;

MIYAMOTO, K .

CELL AND TISSUE RESEARCH, 1988, 251 (01) :51-58

[7] AVIAN GONADOTROPIN-RELEASING HORMONE-I AND HORMONE-II IN BRAIN AND OTHER TISSUES IN TURKEY HENS [J].

MILLAM, JR ;

CRAIGVEIT, CB ;

ADAMS, TE ;

ADAMS, BM .

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-PHYSIOLOGY, 1989, 94 (04) :771-776

[8] RECEPTOR-BINDING AND GONADOTROPIN-RELEASING ACTIVITY OF A NOVEL CHICKEN GONADOTROPIN-RELEASING-HORMONE ([HIS5, TRP7, TYR8]GNRH) AND A D-ARG6 ANALOG [J].

MILLAR, RP ;

MILTON, RCD ;

FOLLETT, BK ;

KING, JA .

ENDOCRINOLOGY, 1986, 119 (01) :224-231

[9] SYNTHESIS, LUTEINIZING-HORMONE-RELEASING ACTIVITY, AND RECEPTOR-BINDING OF CHICKEN HYPOTHALAMIC LUTEINIZING-HORMONE-RELEASING HORMONE [J].

MILLAR, RP ;

KING, JA .

ENDOCRINOLOGY, 1983, 113 (04) :1364-1369

[10] DIFFERENCES IN SALMON GNRH AND CHICKEN GNRH-II CONTENTS IN DISCRETE BRAIN-AREAS OF MALE AND FEMALE RAINBOW-TROUT ACCORDING TO AGE AND STAGE OF MATURITY [J].

OKUZAWA, K ;

AMANO, M ;

KOBAYASHI, M ;

AIDA, K ;

HANYU, I ;

HASEGAWA, Y ;

MIYAMOTO, K .

GENERAL AND COMPARATIVE ENDOCRINOLOGY, 1990, 80 (01) :116-126

← 1 2 →