ENVIRONMENTAL BIOCHEMISTRY OF CURRENT ENVIRONMENTAL LEVELS OF HEAVY-METALS - PREPARATION OF RADIOTRACERS WITH VERY HIGH SPECIFIC RADIOACTIVITY FOR METALLO-BIOCHEMICAL EXPERIMENTS ON LABORATORY-ANIMALS

被引：42

作者：

SABBIONI, E ^{[1
]}

GOETZ, L ^{[1
]}

BIRATTARI, C ^{[1
]}

BONARDI, M ^{[1
]}

机构：

[1] UNIV MILAN,INST PHYS,I-20133 MILAN,ITALY

来源：

SCIENCE OF THE TOTAL ENVIRONMENT | 1981年 / 17卷 / 03期

关键词：

BIOLOGICAL MATERIALS - Chemical Analysis - HEAVY METALS - Toxicity - RADIOACTIVE MATERIALS - Tracers;

D O I：

10.1016/0048-9697(81)90065-6

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

The first part of this paper deals with a definition of the ranges of concentration of trace elements which should be used for metabolic studies on laboratory animals when they are exposed via different routes such as ingestion, inhalation or injection; the second part describes the production of radiotracers with very high specific radioactivity by proton activation in the cyclotron and by neutron irradiation in the nuclear reactor. Their use to label present levels of heavy metals under conditions adapted for biochemical purposes, as well as the preparation of different metal-labelled chemical species is also reported. Particular attention is directed to quality control of the radiotracer solutions which are administered to the animals including those of radioactivity concentrations, radioisotopic purity, radiochemical purity, carrier content and chemical impurities.

引用

页码：257 / 276

页数：20

共 58 条

[1] SIMULTANEOUS DETERMINATION OF 7 TRACE-METALS IN POTABLE WATER USING A VIDICON ATOMIC-ABSORPTION SPECTROMETER [J].