DETECTION OF EPSTEIN-BARR-VIRUS AND HUMAN PAPILLOMAVIRUS IN HEAD AND NECK TUMORS

被引：72

作者：

TYAN, YS

LIU, ST

ONG, WR

CHEN, ML

SHU, CH

CHANG, YS

机构：

[1] CHANG GUNG MED COLL,DEPT MICROBIOL & IMMUNOL,259 WEN HWA 1ST RD,TAOYUAN 33332,TAIWAN

[2] NATL DEF MED COLL,GRAD INST CLIN MED,TAIPEI,TAIWAN

[3] YANG MING MED COLL,GRAD INST MICROBIOL & IMMUNOL,TAIPEI,TAIWAN

[4] VET GEN HOSP,DEPT OTOLARYNGOL,TAIPEI,TAIWAN

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 1993年 / 31卷 / 01期

关键词：

D O I：

10.1128/JCM.31.1.53-56.1993

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The presence of Epstein-Barr virus (EBV) DNA and human papillomavirus (HPV) DNA in 74 head and neck tumor tissues was examined by the polymerase chain reaction and DNA sequencing analysis. EBV DNA sequence was detected in all 30 nasopharyngeal-carcinoma tissue samples and in 30 of 44 other head and neck tumor samples. HPV DNA sequence was detected in 14 of 30 nasopharyngeal-carcinoma tissue samples and in 11 of 44 other tumor samples. Coinfection of both viruses was observed in 14 nasopharyngeal-carcinoma tissue samples but only in 5 other head and neck tumor samples including 3 hypopharyngeal-carcinoma tissue samples. Our data indicate that EBV is closely associated with nasopharyngeal carcinoma and may also be related to hypopharyngeal carcinoma. In addition, a relatively high percentage of EBV-positive nasopharyngeal- and hypopharyngeal-carcinoma tissue specimens contained HPV sequence. The significance of the coexistence of EBV and HPV in these tumor tissues requires further study.

引用

页码：53 / 56

页数：4

共 18 条

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