MULTIFRACTAL RADIOGRAPHIC ANALYSIS OF OSTEOPOROSIS

被引:146
作者
CALIGIURI, P
GIGER, ML
FAVUS, M
机构
[1] UNIV CHICAGO, DEPT RADIOL, KURT ROSSMANN LABS RADIOL IMAGE RES, CHICAGO, IL 60637 USA
[2] UNIV CHICAGO, DEPT MED, CHICAGO, IL 60637 USA
关键词
OSTEOPOROSIS; FRACTAL; MULTIFRACTAL; BONE STRUCTURE; COMPUTER AIDED DIAGNOSIS; BONE RADIOGRAPHY;
D O I
10.1118/1.597390
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
An important complication of osteoporosis is fracture. Alteration in bone structure, as well as decreased bone mass, contribute to the tendency to fracture in osteoporosis. Current methods that measure bone mass alone show substantial overlap of the measurements of osteoporotic patients who fracture with those that do not. Our aim is to develop noninvasive methods of evaluating bone structure on plain film radiographs to better predict fracture risk in osteoporosis. Regions of interest (ROIs) were selected from digitized lateral lumbar spine radiographs of 43 patients being seen in an osteoporosis clinic. The fractal dimension of these ROIs was estimated using a surface area method. The ability of fractal dimension to distinguish between cases that had fracture elsewhere in the spine from those that did not, was evaluated using receiver operating characteristic (ROC) analysis. These results were compared with ROC analysis for these same patients using bone mineral density (BMD) measurements (bone mass). Significantly larger A, (area under ROC curve) values were obtained using fractal dimension (0.87) than from using BMD (0.58), indicating a better test performance using fractal dimension. Therefore, computerized radiographic methods to evaluate bone structure, such as fractal analysis, may be helpful in better determining fracture risk in osteoporosis.
引用
收藏
页码:503 / 508
页数:6
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