PREFRONTAL CORTEX REGULATES BURST FIRING AND TRANSMITTER RELEASE IN RAT MESOLIMBIC DOPAMINE NEURONS STUDIED IN-VIVO

被引：331

作者：

MURASE, S

GRENHOFF, J

CHOUVET, G

GONON, FG

SVENSSON, TH

机构：

[1] KAROLINSKA INST,DEPT PHARMACOL,POB 60400,S-10401 STOCKHOLM 60,SWEDEN

[2] CTR HOSP LYON SUD,INSERM,U171,F-69310 PIERRE BENITE,FRANCE

[3] CTR HOSP LYON SUD,CNRS,URA 1195,F-69310 PIERRE BENITE,FRANCE

来源：

NEUROSCIENCE LETTERS | 1993年 / 157卷 / 01期

关键词：

ACCUMBENS; GLUTAMATE; HYPOFRONTALITY; LIDOCAINE; SINGLE CELL RECORDING; VENTRAL TEGMENTAL AREA; VOLTAMMETRY;

D O I：

10.1016/0304-3940(93)90641-W

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The influence of the medial prefrontal cortex (PFC) on mesolimbic dopamine activity was studied with electrophysiological techniques and in vivo voltammetry in the chloral hydrate-anesthetized male rat. Glutamate injected into the PFC selectively increased burst firing of single dopamine cells in the ventral tegmental area and enhanced the release of dopamine from nerve terminals in the nucleus accumbens. PFC injection of the local anesthetic lidocaine produced the opposite effects on burst firing and terminal release. This selective modulation of the dynamic activity of mesolimbic dopamine neurons by the prefrontal cortex might be important in motivation, learning and schizophrenia.

引用

页码：53 / 56

页数：4

共 21 条

[1]

BEAN AJ, 1991, J NEUROSCI, V11, P2694

[2]

Bjorklund A., 1984, HDB CHEM NEUROANATOM, V2, P55

[3] BURST FIRING OF MESENCEPHALIC DOPAMINE NEURONS IS INHIBITED BY SOMATODENDRITIC APPLICATION OF KYNURENATE [J].