VASOACTIVE INTESTINAL POLYPEPTIDE (VIP) STIMULATES ADENYLATE-CYCLASE IN SELECTED AREAS OF RAT-BRAIN

被引：75

作者：

BORGHI, C

NICOSIA, S

GIACHETTI, A

SAID, SI

机构：

[1] UNIV TEXAS,HLTH SCI CTR,SW MED SCH,DEPT PHARMACOL,DALLAS,TX 75235

[2] UNIV TEXAS,HLTH SCI CTR,SW MED SCH,DEPT INTERNAL MED,DALLAS,TX 75235

[3] VET ADM HOSP,DALLAS,TX 75216

来源：

LIFE SCIENCES | 1979年 / 24卷 / 01期

关键词：

D O I：

10.1016/0024-3205(79)90281-9

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

VIP stimulated adenylate cyclase activity in homogenates of some areas of rat brain that are rich in this peptide, e.g., cerebral cortex, hypothalamus and hippocampus, as well as in cerebellar cortex, where VIP content is low. No stimulation occurred in caudate nucleus or brainstem. The enzyme stimulation was inhibited by Ca2+, but unaffected by guanine nucleotides. Synthetic fragments of VIP (VIP6-28 & VIP14-28) neither stimulated cyclase activity nor inhibited VIP-induced stimulation. © 1979.

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页码：65 / 70

页数：6

相关论文

共 14 条

[1]

BRYANT MG, 1976, LANCET, V1, P991

[2] CHARACTERIZATION OF VIP-SENSITIVE ADENYLATE-CYCLASE IN GUINEA-PIG BRAIN [J].

DESCHODTLANCKMAN, M ;

ROBBERECHT, P ;

CHRISTOPHE, J .

FEBS LETTERS, 1977, 83 (01) :76-80

[3] VASOACTIVE INTESTINAL POLYPEPTIDE (VIP) - VESICULAR LOCALIZATION AND POTASSIUM EVOKED RELEASE FROM RAT HYPOTHALAMUS [J].

EMSON, PC ;

FAHRENKRUG, J ;

SCHAFFALITZKYDEMUCKADELL, OB ;

JESSELL, TM ;

IVERSEN, LL .

BRAIN RESEARCH, 1978, 143 (01) :174-178

[4] VASOACTIVE INTESTINAL POLYPEPTIDE (VIP) IN HUMAN CEREBROSPINAL-FLUID [J].

FAHRENKRUG, J ;

SCHAFFALITZKYDEMUCKADELL, OB ;

FAHRENKRUG, A .

BRAIN RESEARCH, 1977, 124 (03) :581-584

[5] VASOACTIVE INTESTINAL POLYPEPTIDE AND NERVOUS-SYSTEM - IMMUNOHISTOCHEMICAL EVIDENCE FOR LOCALIZATION IN CENTRAL AND PERIPHERAL NEURONS, PARTICULARLY INTRACORTICAL NEURONS OF CEREBRAL-CORTEX [J].

FUXE, K ;

HOKFELT, T ;

SAID, SI ;

MUTT, V .

NEUROSCIENCE LETTERS, 1977, 5 (05) :241-246

[6] VASOACTIVE INTESTINAL POLYPEPTIDE IN BRAIN - LOCALIZATION IN AND RELEASE FROM ISOLATED NERVE-TERMINALS [J].

GIACHETTI, A ;

SAID, SI ;

REYNOLDS, RC ;

KONIGES, FC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (08) :3424-3428

[7]

HUBEL KA, 1978, GASTROENTEROLOGY, V74, P1127

[8]

LABURTHE M, 1978, MEMBRANE PROTEINS, V45, P271

[9] POLYPEPTIDE WITH BROAD BIOLOGICAL ACTIVITY - ISOLATION FROM SMALL INTESTINE [J].

SAID, SI ;

MUTT, V .

SCIENCE, 1970, 169 (3951) :1217-&

[10] VASOACTIVE INTESTINAL POLYPEPTIDE - ABUNDANT IMMUNOREACTIVITY IN NEURAL CELL LINES AND NORMAL NERVOUS-TISSUE [J].

SAID, SI ;

ROSENBERG, RN .

SCIENCE, 1976, 192 (4242) :907-908