ANTI-ANAPHYLACTIC AND BRONCHODILATING ACTION OF A BETA-ADRENOCEPTOR STIMULATOR, KWD-2131, IN HUMAN-LUNG TISSUE

The beta‐adrenoceptor stimulating agent KWD 2131 has been studied with regard to inhibitory effect on allergen‐induced histamine release from passively sensitized human lung tissue and relaxing effect on contracted small (diameter= 1 mm) and large (diameter 3 mm) isolated human bronchi. The dose for 50% inhibition of the allergen‐induced histamine release was 2 × 10−11 M. The potency of KWD 2131 was approximately 0.15 times that of terbutaline and 0.05 times that of isoprenaline in this respect. The bronchodilating potency‐ of KWD 2131 was 0.02–0.03 times that of terbutaline. The data indicate that KWD 2131 is a compound with preferably anti‐anaphylactic potency in the human lung. Copyright © 1979, Wiley Blackwell. All rights reserved