NERVE-FIBER OUTGROWTH FROM DORSAL ROOT-GANGLIA - ION DEPENDENCY OF NERVE GROWTH-FACTOR ACTION

被引：10

作者：

STACH, RW ^{[1
]}

STACH, BM ^{[1
]}

WEST, NR ^{[1
]}

机构：

[1] SUNY UPSTATE MED CTR, DEPT BIOCH & PHARMACOL, SYRACUSE, NY 13210 USA

来源：

JOURNAL OF NEUROCHEMISTRY | 1979年 / 33卷 / 04期

关键词：

D O I：

10.1111/j.1471-4159.1979.tb09914.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Abstract– Embryonic sensory neurons have an absolute requirement for the nerve growth factor to survive and grow fibers, at least in vitro. We have now shown that the inorganic cations, magnesium and potassium are also necessary for the survival of these cells. On the other hand, calcium is not needed for the survival of the sensory neurons, but is needed for the neurons to grow fibers. Therefore, by changing the concentration of calcium ions in the culture medium it is possible to separate the two actions (survival and fiber outgrowth) of the nerve growth factor on sensory neurons. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：845 / 855

页数：11

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