MICROBIAL O-CARBAMYLATION OF NOVOBIOCIN

被引：13

作者：

KUO, MS

YUREK, DA

CHIRBY, DG

CIALDELLA, JI

MARSHALL, VP

机构：

[1] Upjohn Laboratories, The Upjohn Company, Kalamazoo

来源：

JOURNAL OF ANTIBIOTICS | 1991年 / 44卷 / 10期

关键词：

D O I：

10.7164/antibiotics.44.1096

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Novobiocin was inactivated by Streptomyces niveus US 2094 in fermentation. The inactivation product was isolated and characterized by NMR and MS as 2''-O-carbamylnovobiocin. The MICs of novobiocin and 2''-O-carbamylnovobiocin were determined for S. niveus strains.

引用

收藏

页码：1096 / 1100

页数：5

相关论文

共 13 条

[1] ORIGIN AND EVOLUTION OF GENES SPECIFYING RESISTANCE TO MACROLIDE, LINCOSAMIDE AND STREPTOGRAMIN ANTIBIOTICS - DATA AND HYPOTHESES [J].

ARTHUR, M ;

BRISSONNOEL, A ;

COURVALIN, P .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 1987, 20 (06) :783-802

[2] AMINOGLYCOSIDE ANTIBIOTIC-INACTIVATING ENZYMES IN ACTINOMYCETES SIMILAR TO THOSE PRESENT IN CLINICAL ISOLATES OF ANTIBIOTIC-RESISTANT BACTERIA [J].

BENVENISTE, R ;

DAVIES, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1973, 70 (08) :2276-2280

[3]

BREITMAIER E, 1978, 13C NMR SPECTROSCOPY, P74

[4]

BRISSONNOEL A, 1988, J BIOL CHEM, V263, P15880

[5]

HOEKSEMA HERMAN, 1956, ANTIBIOT AND CHEMOTHER, V6, P143

[6] ASSIGNMENT OF CARBONYL CARBONS AND SEQUENCE-ANALYSIS IN PEPTIDES BY HETERONUCLEAR SHIFT CORRELATION VIA SMALL COUPLING-CONSTANTS WITH BROAD-BAND DECOUPLING IN T1 (COLOC) [J].

KESSLER, H ;

GRIESINGER, C ;

ZARBOCK, J ;

LOOSLI, HR .

JOURNAL OF MAGNETIC RESONANCE, 1984, 57 (02) :331-336

[7] MICROBIAL GLYCOSYLATION OF ERYTHROMYCIN-A [J].

KUO, MS ;

CHIRBY, DG ;

ARGOUDELIS, AD ;

CIALDELLA, JI ;

COATS, JH ;

MARSHALL, VP .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1989, 33 (12) :2089-2091

[8]

MARSHALL VP, 1987, ANTIBIOTICS MICROBIA, P7

[9] DEGENERATION OF STREPTOMYCES NIVEUS WITH REPEATED TRANSFERS [J].

REUSSER, F ;

SAVAGE, GM ;

KOEPSELL, HJ .

APPLIED MICROBIOLOGY, 1961, 9 (04) :342-&

[10] MICROBIAL HYDROXYLATION OF NOVOBIOCIN AND RELATED-COMPOUNDS [J].

SEBEK, OK ;

DOLAK, LA .

JOURNAL OF ANTIBIOTICS, 1984, 37 (02) :136-142