CSF BACLOFEN LEVELS AFTER INTRATHECAL ADMINISTRATION IN SEVERE SPASTICITY

被引：49

作者：

SALLERINCAUTE, B

LAZORTHES, Y

MONSARRAT, B

CROS, J

BASTIDE, R

机构：

[1] FAC SCI PHARMACEUT TOULOUSE,PHARM GALEN LAB,TOULOUSE,FRANCE

[2] CHU TOULOUSE RANGUEIL,NEUROCHIRURG CLIN,NEUROCHIRURG & NEUROBIOL APPL LAB,TOULOUSE,FRANCE

来源：

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 1991年 / 40卷 / 04期

关键词：

BACLOFEN; SEVERE SPASTICITY; PHARMACOKINETICS; CSF; INTRATHECAL INJECTION;

D O I：

10.1007/BF00265844

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The pharmacokinetic parameters in the CSF of baclofen given to 4 patients as an intrathecal bolus are reported. Considerable inter-individual variability in the parameters was observed. The elimination half-life ranged from 0.9 to 5 h and the clearance from 0.013 to 0.081.h-1. In order to optimize treatment, it is suggested that CSF baclofen levels be matched to changes in Hoffman's monosynaptic reflex (H reflex).

引用

页码：363 / 365

页数：3

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