L-687,781, A NEW MEMBER OF THE PAPULACANDIN FAMILY OF BETA-1,3-D-GLUCAN SYNTHESIS INHIBITORS .2. FERMENTATION, ISOLATION, AND BIOLOGICAL-ACTIVITY

被引：57

作者：

VANMIDDLESWORTH, F

OMSTEAD, MN

SCHMATZ, D

BARTIZAL, K

FROMTLING, R

BILLS, G

NOLLSTADT, K

HONEYCUTT, S

ZWEERINK, M

GARRITY, G

WILSON, K

机构：

[1] Merck, Sharp & Dohme Research Laboratories, Rahway

来源：

JOURNAL OF ANTIBIOTICS | 1991年 / 44卷 / 01期

关键词：

D O I：

10.7164/antibiotics.44.45

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new beta-1,3-D-glucan synthesis inhibitor, L-687,781 is produced by the cultivation of Dictyochaeta simplex ATCC 20960. L-687,781 exhibits potent in vitro antifungal activity as well as anti-Pneumocystis activity in a rat model.

引用

页码：45 / 51

页数：7

共 16 条

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