L-687,781, A NEW MEMBER OF THE PAPULACANDIN FAMILY OF BETA-1,3-D-GLUCAN SYNTHESIS INHIBITORS .2. FERMENTATION, ISOLATION, AND BIOLOGICAL-ACTIVITY

被引:57
作者
VANMIDDLESWORTH, F
OMSTEAD, MN
SCHMATZ, D
BARTIZAL, K
FROMTLING, R
BILLS, G
NOLLSTADT, K
HONEYCUTT, S
ZWEERINK, M
GARRITY, G
WILSON, K
机构
[1] Merck, Sharp & Dohme Research Laboratories, Rahway
关键词
D O I
10.7164/antibiotics.44.45
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
A new beta-1,3-D-glucan synthesis inhibitor, L-687,781 is produced by the cultivation of Dictyochaeta simplex ATCC 20960. L-687,781 exhibits potent in vitro antifungal activity as well as anti-Pneumocystis activity in a rat model.
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页码:45 / 51
页数:7
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