DOPAMINERGIC REGULATION OF PRE-PRONPY MESSENGER-RNA LEVELS IN THE RAT ARCUATE NUCLEUS

被引：34

作者：

PELLETIER, G ^{[1
]}

SIMARD, J ^{[1
]}

机构：

[1] UNIV LAVAL,MED CTR,MRC,MOLEC ENDOCRINOL GRP,QUEBEC CITY G1K 7P4,QUEBEC,CANADA

来源：

NEUROSCIENCE LETTERS | 1991年 / 127卷 / 01期

关键词：

NEUROPEPTIDE-Y; ARCUATE NUCLEUS; DOPAMINE; INSITU HYBRIDIZATION;

D O I：

10.1016/0304-3940(91)90903-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In order to study the role of dopamine on neuropeptide Y (NPY) gene expression in the rat arcuate nucleus, we evaluated the effects of haloperidol, a dopaminergic antagonist, and bromocriptine, a D2 dopamine receptor agonist, on the levels of pre-proNPY mRNA as measured by in situ hybridization. Chronic treatment with bromocriptine produced a moderate decrease of the hybridization signal, whereas haloperidol treatment resulted in a marked increase in signal intensities. These results indicate that, in the arcuate nucleus, NPY neurons are negatively regulated by dopaminergic-mediated mechanisms acting most likely through D2 receptors.

引用

页码：96 / 98

页数：3

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