ZOLLINGER-ELLISON SYNDROME - PROSPECTIVE ASSESSMENT OF ABDOMINAL US IN THE LOCALIZATION OF GASTRINOMAS

被引:44
作者
LONDON, JF
SHAWKER, TH
DOPPMAN, JL
FRUCHT, HH
VINAYEK, R
STARK, HA
MILLER, LS
MILLER, DL
NORTON, JA
JENSEN, RT
GARDNER, JD
MATON, PN
机构
[1] NIDDKD,DIGEST DIS BRANCH,BLDG 10,RM 9C-103,BETHESDA,MD 20892
[2] NCI,SURG BRANCH,BETHESDA,MD 20892
[3] NIH,WARREN MAGNUSON CLIN CTR,BETHESDA,MD 20892
关键词
DUODENUM; NEOPLASMS; LIVER; US STUDIES; LIVER NEOPLASMS; SECONDARY; PANCREAS;
D O I
10.1148/radiology.178.3.1994415
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
The ability of abdominal ultrasound (US) to help localize gastrinomas was prospectively studied in 79 patients with Zollinger-Ellison syndrome. The results were assessed by means of laparotomy, autopsy, or percutaneous liver biopsy. For hepatic gastrinoma, US had a sensitivity of 63% and a specificity of 100%, with a positive predictive value of 100% and a negative predictive value of 89%. US was slightly less sensitive for detecting gastrinoma in the liver than were computed tomography (CT) (66%) and selective angiography (78%). For detection of extrahepatic gastrinoma, US had a sensitivity of 30%, a specificity of 94%, a positive predictive value of 100%, and a negative predictive value of 25%. US enabled detection of tumor in eight cases not detected with CT and in four not detected with angiography. Specificity for extrahepatic gastrinoma was similar for all three modalities (89%-95%). CT and US were equally effective for the detection of extrahepatic gastrinoma, and angiography was significantly more effective than both US and CT (P < .01). The authors conclude that US, although of low sensitivity, remains useful as the initial imaging modality in patients with Zollinger-Ellison syndrome.
引用
收藏
页码:763 / 767
页数:5
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