SYNTHESIS OF SUBSTITUTED 2-AMINOTHIAZOLES

被引：26

作者：

LIN, Y

SEIFERT, CM

KANG, SM

DUSZA, JP

LANG, SA

机构：

[1] Infectious Disease Research Section, Medical Research Division, Lederle Laboratories, American Cyanamid Company, Pearl River, New York

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1979年 / 16卷 / 07期

关键词：

D O I：

10.1002/jhet.5570160718

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The preparation of 4‐ and 5‐acyl‐ and aroyl‐2‐substituted aminothiazoles is described. The condensation of thioureas with acyl halides leading to 4,5‐disubstituted‐2‐aminothiazoles and 7‐(4H)benzothiazolones is discussed. A discussion of the isolation of various intermediates and the mechanistic pathway is also included. A number of 2‐anilino or 2‐benzyl‐4‐ or 5‐aroylthiazoles possessed moderate oral antitubercolosis activity (2). Copyright © 1979 Journal of Heterocyclic Chemistry

引用

页码：1377 / 1383

页数：7

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