AGE-DEPENDENT CHANGES IN THE MITOCHONDRIAL F0F1 ATP SYNTHASE

被引：35

作者：

GUERRIERI, F

CAPOZZA, G

KALOUS, M

ZANOTTI, F

DRAHOTA, Z

PAPA, S

机构：

[1] UNIV BARI, CNR, CTR STUDY MITOCHONDRIA & ENERGY METAB, I-70124 BARI, ITALY

[2] CZECHOSLOVAK ACAD SCI, INST PHYSIOL, CS-11142 PRAGUE 1, CZECHOSLOVAKIA

来源：

ARCHIVES OF GERONTOLOGY AND GERIATRICS | 1992年 / 14卷 / 03期

关键词：

AGING; F0F1 ATP SYNTHASE; HEART MITOCHONDRIA; ENZYME; F0F1 ATP SYNTHASE (EC 3.6.1.34);

D O I：

10.1016/0167-4943(92)90029-4

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The age dependence of ATP hydrolase activity and oligomycin sensitive passive proton conduction in sonicated submitochondrial particles of rat brain and rat heart has been investigated. The results show an increase of V(max) of the ATP hydrolase activity and decrease of oligomycin sensitive passive proton conduction with increase of the age of rats from 3 to 6 months. Decrease of ATPase activity and increase of oligomycin sensitive proton conduction occur with further aging to 24 months. Immunoblot analysis shows that both the F1 and F(o) contents of mitochondria vary with the age of rats, the former exhibiting relatively larger changes.

引用

页码：299 / 308

页数：10

共 25 条

[1] FACTORS INVOLVED IN THE AGE-RELATED ALTERATION IN THE EFFICIENCY OF THE BRAIN BIOENERGETICS [J].