INCREASE OF METHYLGUANIDINE AND GUANIDINOACETIC ACID IN THE BRAIN OF AMYGDALA-KINDLED RATS

被引：20

作者：

HIRAYASU, Y ^{[1
]}

MORIMOTO, K ^{[1
]}

OTSUKI, S ^{[1
]}

机构：

[1] OKAYAMA UNIV,SCH MED,DEPT NEUROPSYCHIAT,OKAYAMA 700,JAPAN

来源：

EPILEPSIA | 1991年 / 32卷 / 06期

关键词：

CONVULSIONS; NEUROLOGIC MODELS; AMYGDALA; GUANIDINO COMPOUNDS; RATS; CONVULSANTS;

D O I：

10.1111/j.1528-1157.1991.tb05531.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Guanidino compounds are intrinsic chemoconvulsants. We investigated the regional and time-dependent changes of these compounds in the amygdala (AM) of kindled rats versus electroconvulsive shock (ECS) seizures using high-performance liquid chromatography (HPLC). Twenty-eight days after the last AM-kindled seizure, guanidinoacetic acid (GAA) and methylguanidine (MG) levels were significantly increased in the bilateral AM as compared with those of control rats, which had been implanted with electrodes but were not stimulated. Both compounds, however, tended to decrease in the bilateral AM after ECS seizure. In addition, we measured these compounds after induction of one afterdischarge AD) in the AM. These compounds increased significantly 7 days after AD was induced in the ipsilateral AM. We suggest that the increase of these compounds is coincident with AD generation and specific to AM kindling and the kindled state.

引用

页码：761 / 766

页数：6

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