CLONAL FIBROBLASTIC CELL-LINES ESTABLISHED FROM A HEAVILY EXPOSED ATOMIC-BOMB SURVIVOR

被引：5

作者：

HONDA, T ^{[1
]}

SADAMORI, N ^{[1
]}

ITOH, M ^{[1
]}

KUSUMI, O ^{[1
]}

机构：

[1] NAGASAKI UNIV,SCH MED,INST ATOM DIS,DEPT INTERNAL MED,NAGASAKI 852,JAPAN

来源：

MUTATION RESEARCH | 1993年 / 291卷 / 02期

关键词：

ATOMIC BOMB SURVIVOR; CLONAL CELL LINE; EXTENDED INVITRO LIFE SPAN;

D O I：

10.1016/0165-1161(93)90151-O

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Two clonal fibroblastic cell lines with simple chromosome aberrations - one with del(3)(p24) and the other with t(1;16)(q21;q11.2) - were established from a high dose (5.14 Gy) female atomic bomb survivor by serial culture of skin fibroblasts. These two types of clonal cells showed a more extended life span than did the cells with 44 other types of chromosome aberrations and normal cells. In addition to these results, a prominent clonal population was observed in the peripheral blood cells in this subject. It is assumed that these clonal populations arose in vivo as a result of radiation exposure to the atomic bomb.

引用

页码：125 / 133

页数：9

共 13 条

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