RELATIONSHIP BETWEEN HYPOPHYSEAL PORTAL GHRH AND SOMATOSTATIN AND PERIPHERAL GH LEVELS IN THE CONSCIOUS SHEEP

被引:27
作者
CATALDI, M
MAGNAN, E
GUILLAUME, V
DUTOUR, A
CONTEDEVOLX, B
LOMBARDI, G
OLIVER, C
机构
[1] FAC MED NORD, INST FEDERAT JEAN ROCHE,INSERM,U297, NEUROENDOCRINOL EXPTL LAB, F-13916 MARSEILLE 20, FRANCE
[2] FAC MED NAPLES, IST ENDOCRINOL, NAPLES, ITALY
来源
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION | 1994年 / 17卷 / 09期
关键词
GHRH; SOMATOSTATIN; GH SECRETION; HYPOPHYSEAL PORTAL BLOOD;
D O I
10.1007/BF03347767
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The mechanisms involved in the genesis of pulsatile GH secretion are not well understood. Recently, methods for hypophyseal portal blood collection in conscious sheep became available. Using this method, GHRH and SRIH secretion into hypophyseal portal blood (HPB) and GH release from the pituitary gland were simultaneous assessed and the relationship between GHRH and SRIH changes in HPB and GH in peripheral blood was investigated. In 23 rams (9-11 month old, 35-45 kg bw), 126 hours of HPB were analysed. Fifty-four spontaneous GH peaks were detected. The majority of GH peaks (48.1%) was associated with an increased portal GHRH and a fall in somatostatin concentrations. A simultaneous increase in GHRH and somatostatin levels was observed in 18.5% of GH peaks while 12.9% of peaks occurred with a fall in SRIH and no modification in GHRH concentrations. Finally, 5/54 (9.3%) GH peaks occurred without any modification in portal GHRH and SRIH release. Our data indicate that the GHRH/SRIH interplay is complex. The occurrence of spontaneous GH peaks may be due not only to a coordinate increase in GHRH and reduction in SRIH release similar to male rat, but also to other patterns of GHRH/SRIH secretion.
引用
收藏
页码:717 / 722
页数:6
相关论文
共 33 条
[1]   EFFECT OF NUTRITION AND IMMUNIZATION AGAINST SOMATOSTATIN ON GROWTH AND INSULIN-LIKE GROWTH-FACTORS IN SHEEP [J].
BASS, JJ ;
GLUCKMAN, PD ;
FAIRCLOUGH, RJ ;
PETERSON, AJ ;
DAVIS, SR ;
CARTER, WD .
JOURNAL OF ENDOCRINOLOGY, 1987, 112 (01) :27-31
[2]  
BURGER HG, 1972, J LAB CLIN MED, V80, P302
[3]   THE REBOUND RELEASE OF GROWTH-HORMONE (GH) FOLLOWING SOMATOSTATIN INFUSION IN RATS INVOLVES HYPOTHALAMIC GH-RELEASING FACTOR RELEASE [J].
CLARK, RG ;
CARLSSON, LMS ;
RAFFERTY, B ;
ROBINSON, ICAF .
JOURNAL OF ENDOCRINOLOGY, 1988, 119 (03) :397-404
[4]   INTRAVENOUS GROWTH-HORMONE - GROWTH-RESPONSES TO PATTERNED INFUSIONS IN HYPOPHYSECTOMIZED RATS [J].
CLARK, RG ;
JANSSON, JO ;
ISAKSSON, O ;
ROBINSON, ICAF .
JOURNAL OF ENDOCRINOLOGY, 1985, 104 (01) :53-61
[5]   CHARACTERISTICS OF THE POST-SOMATOSTATIN REBOUND IN GROWTH-HORMONE SECRETION FROM PERIFUSED SOMATOTROPHS [J].
COWAN, JS ;
MOOR, B ;
CHOW, A ;
KRAICER, J .
ENDOCRINOLOGY, 1983, 113 (03) :1056-1061
[6]   SOMATOSTATIN - ITS INFLUENCE ON PLASMA-LEVELS OF GROWTH-HORMONE, PROLACTIN AND THYROTROPIN IN SHEEP [J].
DAVIS, SL .
JOURNAL OF ANIMAL SCIENCE, 1975, 40 (05) :911-916
[7]   AGE-RELATED AND SEX-RELATED DIFFERENCES IN EPISODIC GROWTH-HORMONE SECRETION IN THE RAT [J].
EDEN, S .
ENDOCRINOLOGY, 1979, 105 (02) :555-560
[8]   COMBINED AUTORADIOGRAPHIC AND IMMUNOHISTOCHEMICAL EVIDENCE FOR AN ASSOCIATION OF SOMATOSTATIN BINDING-SITES WITH GROWTH HORMONE-RELEASING FACTOR-CONTAINING NERVE-CELL BODIES IN THE RAT ARCUATE NUCLEUS [J].
EPELBAUM, J ;
MOYSE, E ;
TANNENBAUM, GS ;
KORDON, C ;
BEAUDET, A .
JOURNAL OF NEUROENDOCRINOLOGY, 1989, 1 (02) :109-115
[9]   AGE-RELATED CHANGE IN 24-HOUR SPONTANEOUS SECRETION OF GROWTH-HORMONE [J].
FINKELSTEIN, JW ;
ROFFWARG, HP ;
KREAM, J ;
BOYAR, RM ;
HELLMAN, L .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1972, 35 (05) :665-+
[10]   MEASUREMENT OF GROWTH HORMONE-RELEASING HORMONE AND SOMATOSTATIN IN HYPOTHALAMIC-PORTAL PLASMA OF UNANESTHETIZED SHEEP - SPONTANEOUS SECRETION AND RESPONSE TO INSULIN-INDUCED HYPOGLYCEMIA [J].
FROHMAN, LA ;
DOWNS, TR ;
CLARKE, IJ ;
THOMAS, GB .
JOURNAL OF CLINICAL INVESTIGATION, 1990, 86 (01) :17-24