THE THYMOSIN BETA(4) GENE IS STRONGLY ACTIVATED IN NEURAL TISSUES DURING EARLY POSTIMPLANTATION MOUSE DEVELOPMENT

被引：20

作者：

CARPINTERO, P

ANADON, R

DELAMO, FF

GOMEZMARQUEZ, J

机构：

[1] UNIV SANTIAGO DE COMPOSTELA,FAC BIOL,DEPT BIOQUIM & BIOL MOLEC,SANTIAGO,SPAIN

[2] UNIV SANTIAGO DE COMPOSTELA,FAC BIOL,DEPT BIOL FUNDAMENTAL,SANTIAGO,SPAIN

来源：

NEUROSCIENCE LETTERS | 1995年 / 184卷 / 01期

关键词：

THYMOSIN BETA(4); ACTIN-BINDING PROTEINS; KOLMER CELLS; MOUSE DEVELOPMENT; NEUROEMBRYOGENESIS;

D O I：

10.1016/0304-3940(94)11169-J

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We studied the temporal and spatial distribution of the mRNA encoding for thymosin beta(4) (T beta(4)), a Small acidic actin-sequestering peptide, during the early postimplantation mouse development. Analysis of total embryo RNA demonstrated a strong activation of T beta(4) gene after gastrulation and coincident with neurulation. In situ hybridization showed that T beta(4) mRNA was strongly expressed in the central nervous system and peripheral ganglia, paralleling the gradient of neuronal differentiation. An intense signal was also observed in intraventricular macrophages and blood vessels. The role of T beta(4) in mammalian neuroembryogenesis is discussed.

引用

页码：63 / 66

页数：4

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