FREQUENT USE OF MENFEGOL SPERMICIDAL VAGINAL FOAMING TABLETS ASSOCIATED WITH A HIGH-INCIDENCE OF GENITAL LESIONS

被引:19
作者
GOEMAN, J
NDOYE, I
SAKHO, LM
MBOUP, S
PIOT, P
KARAM, M
BELSEY, E
LANGE, JMA
LAGA, M
PERRIENS, JH
机构
[1] WHO,DIV RES & INTERVENT DEV,GLOBAL PROGRAMME AIDS,CH-1211 GENEVA,SWITZERLAND
[2] INST TROP MED,DEPT INFECT & IMMUN,ANTWERP,BELGIUM
[3] HOP A LE DANTEC,BACTERIOL & VIROL LAB,DAKAR,SENEGAL
关键词
D O I
10.1093/infdis/171.6.1611
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Menfegol is a spermicide with in vitro activity against human immunodeficiency virus (HIV), A randomized placebo-controlled safety study covered the use of menfegol foaming tablets for 14 days at increasing frequencies of insertion by 125 prostitutes in Dakar, Senegal. The frequencies of colposcopically diagnosed genital lesions were 5.0%, 11.8%, 27.8%, 49.7%, and 29.4% among menfegol recipients when tablets were used once every other day or 1, 2, 4, or 8 times a day, respectively (P < .05), Among placebo recipients, frequencies were 11.1% and 23.5% when tablets were used <8 times daily and 8 times daily, respectively, There was no association between subjective genital symptoms and the incidence of colposcopically detected lesions, The high incidence of genital lesions when menfegol foaming tablets were used more than once daily suggests that their frequent use should not be recommended to prevent HIV transmission, In use at low frequency, the tablets' toxicity might be balanced by anti-HIV properties, Safety studies on vaginal microbicides should use objective methods, such as colposcopy, to assess the incidence of lesions.
引用
收藏
页码:1611 / 1614
页数:4
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