LIGAND PROTEIN DOCKING AND RATIONAL DRUG DESIGN

被引：122

作者：

LYBRAND, TP

机构：

[1] University of Washington, Molecular Bioengineering Program, Seattle, WA 98195

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1995年 / 5卷 / 02期

关键词：

D O I：

10.1016/0959-440X(95)80080-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Over the past year there have been some interesting and significant advances in computer-based ligand-protein docking techniques and related rational drug-design tools, including flexible ligand docking and better estimation of binding free energies and solvation energies. As a result, the successful use of computational tools to help generate interesting new guide (lead) compounds for targeted receptors is becoming more commonplace.

引用

收藏

页码：224 / 228

页数：5

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