MODULATION OF KC/GRO PROTEIN (INTERLEUKIN-8 RELATED PROTEIN IN RODENTS) RELEASE FROM HEPATOCYTES BY BIOLOGICALLY-ACTIVE MEDIATORS

被引：27

作者：

SHIRATORI, Y ^{[1
]}

HIKIBA, Y ^{[1
]}

MAWET, E ^{[1
]}

NIWA, Y ^{[1
]}

MATSUMURA, M ^{[1
]}

KATO, N ^{[1
]}

SHIINA, S ^{[1
]}

TADA, M ^{[1
]}

KOMATSU, Y ^{[1
]}

KAWABE, T ^{[1
]}

YOSHIDA, H ^{[1
]}

OKANO, K ^{[1
]}

OMATA, M ^{[1
]}

机构：

[1] UNIV TOKYO, FAC MED, DEPT INTERNAL MED 2, TOKYO 113, JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 203卷 / 03期

关键词：

D O I：

10.1006/bbrc.1994.2340

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Modulation of the release of KC/gro protein (a chemoattractant for neutrophils; IL-8 related protein in rodents) from isolated hepatocytes after stimulation with biologically active mediators was investigated. The release of KC/gro protein from hepatocytes of control rats was enhanced by stimulation with lipopolysaccharide, IL-1beta or TNF-alpha in a dose dependent manner, but was not enhanced by IL-6. In contrast, although spontaneous release of KC/gro protein from the hepatocytes of chronically ethanol-fed rats was markedly enhanced as compared with control rats, the relative increase by stimulation with lipopolysaccharide, IL 1beta or TNF-alpha was significantly smaller than in controls. These findings suggest that the regulation of hepatocyte KC/gro protein production might be disturbed in chronically ethanol-fed rats. (C) 1994 Academic Press, Inc.

引用

页码：1398 / 1403

页数：6

共 23 条

[1] ENDOTOXIN INDUCED HEPATIC-NECROSIS IN RATS ON AN ALCOHOL DIET
BHAGWANDEEN, BS
APTE, M
MANWARRING, L
DICKESON, J
[J]. JOURNAL OF PATHOLOGY, 1987, 152 (01) : 47 - 53
[2] BIRD GLA, 1993, ADV BIOSCI, V86, P133
[3] BJARNASON I, 1984, LANCET, V1, P179
[4] ENDOTOXEMIA IN PATIENTS WITH ALCOHOLIC AND NONALCOHOLIC CIRRHOSIS AND IN SUBJECTS WITH NO EVIDENCE OF CHRONIC LIVER-DISEASE FOLLOWING ACUTE ALCOHOL EXCESS
BODE, C
KUGLER, V
BODE, JC
[J]. JOURNAL OF HEPATOLOGY, 1987, 4 (01) : 8 - 14
[5] POLYMORPHONUCLEAR LEUKOCYTE-MEDIATED CELL AND TISSUE-INJURY - OXYGEN METABOLITES AND THEIR RELATIONS TO HUMAN-DISEASE
FANTONE, JC
WARD, PA
[J]. HUMAN PATHOLOGY, 1985, 16 (10) : 973 - 978
[6] PATHOLOGY OF ALCOHOLIC LIVER-DISEASE
FRENCH, SW
NASH, J
SHITABATA, P
KACHI, K
HARA, C
CHEDID, A
MENDENHALL, CL
[J]. SEMINARS IN LIVER DISEASE, 1993, 13 (02) : 154 - 169
[7] INTERLEUKIN-8 IN SEPSIS - RELATION TO SHOCK AND INFLAMMATORY MEDIATORS
HACK, CE
HART, M
VANSCHIJNDEL, RJMS
EERENBERG, AJM
NUIJENS, JH
THIJS, LG
AARDEN, LA
[J]. INFECTION AND IMMUNITY, 1992, 60 (07) : 2835 - 2842
[8] KHORUTS A, 1991, HEPATOLOGY, V13, P267, DOI 10.1002/hep.1840130211
[9] CLEAVAGE OF STRUCTURAL PROTEINS DURING ASSEMBLY OF HEAD OF BACTERIOPHAGE-T4
LAEMMLI, UK
[J]. NATURE, 1970, 227 (5259) : 680 - +
[10] EXPERIMENTAL METHODS OF ETHANOL ADMINISTRATION
LIEBER, CS
DECARLI, LM
SORRELL, MF
[J]. HEPATOLOGY, 1989, 10 (04) : 501 - 510

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