HEMOLYTIC-UREMIC SYNDROME DUE TO DEOXYCOFORMYCIN - A REPORT OF THE 2ND CASE

被引：19

作者：

SAKAI, C

TAKAGI, T

WAKATSUKI, S

MATSUZAKI, O

机构：

[1] Division of the Hematology and Chemotherapy, Chiba Cancer Center Hospital, Chiba

[2] Division of Surgical Pathology, Chiba Cancer Center Hospital, Chiba

来源：

INTERNAL MEDICINE | 1995年 / 34卷 / 06期

关键词：

ADULT T-CELL LEUKEMIA; MICROANGIOPATHIC HEMOLYTIC ANEMIA; RENAL FAILURE; HYPERTENSION;

D O I：

10.2169/internalmedicine.34.593

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A hypercalcemic patient with adult T-cell leukemia was treated with deoxycoformycin (DCF) in a dose of 5 mg/m(2) daily for three days, Several days later, severe thrombocytopenia appeared abruptly and then microangiopathic hemolytic anemia ensued, Subsequently, renal failure and hypertension developed, and the patient died seven weeks after DCF therapy, Needle necropsy of the kidney showed glomerular damage including swelling of endothelial cells, mesangiolysis and segmental collapse, This is the second reported case of hemolytic-uremic syndrome due to DCF.

引用

页码：593 / 596

页数：4

共 23 条

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