Potential protection from toxicity by oral iron chelators

被引：41

作者：

Hider, RC

机构：

[1] Department of Pharmacy, King's College London, London, SW3 6LX, Manresa Road

来源：

TOXICOLOGY LETTERS | 1995年 / 82-3卷

关键词：

iron chelators; oral activity; metalloenzymes; hydroxypyridinones; cell cycle;

D O I：

10.1016/0378-4274(95)03606-7

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The design of clinically useful iron chelators requires attention to be paid to 3 key parameters: oral absorption, selectivity and affinity for iron(III) and toxicity. Factors which influence these 3 parameters are discussed. Hydroxypyridinones are identified as key ligands and properties leading to minimal toxicity and optimum distribution for the treatment of thalassaemia are presented. Key metalloenzymes which are inhibited by iron chelators are identified.

引用

页码：961 / 967

页数：7

共 23 条

[1]

ABEYSINGHE RD, 1995, UNPUB BIOCH PHARM

[2]

BRITTENHAM GM, 1992, BLOOD, V80, P569

[3] HUMAN FERROCHELATASE IS AN IRON-SULFUR PROTEIN [J].