1,2,3,4,5,6-HEXAHYDRO-6-PHENYL-2,6-METHANO-3-BENZAZOCINES .I. 3-CARBOXAMIDO-8-HYDROXY DERIVATIVE AS AN ORALLY EFFECTIVE ANALGETIC

被引：7

作者：

BLOCK, FB

CLARKE, FH

机构：

[1] Department of Medicinal Chemistry, Pharmaceutical Division, Geigy Chemical Corporation, Ardsley, New York

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1969年 / 12卷 / 05期

关键词：

D O I：

10.1021/jm00305a029

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of 3-carboxarmdo-1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazoein-8-ol (VII) is described. In a preliminary clinical trial VII has been shown to be an orally effective analgetic. This compound has an unusual freedom from toxicity in rats and dogs, and from physical dependence capacity in the monkey. © 1969, American Chemical Society. All rights reserved.

引用

页码：845 / &

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[5]

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[9]

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[10]

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