AMINO TERMINAL AMINO-ACID SEQUENCE OF MACROMOMYCIN, A PROTEIN ANTI-TUMOR ANTIBIOTIC

被引：11

作者：

SAWYER, TH ^{[1
]}

GUETZOW, K ^{[1
]}

OLSON, MOJ ^{[1
]}

BUSCH, H ^{[1
]}

PRESTAYKO, AW ^{[1
]}

CROOKE, ST ^{[1
]}

机构：

[1] BRISTOL MYERS CO LABS,SYRACUSE,NY 13201

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1979年 / 86卷 / 04期

关键词：

D O I：

10.1016/0006-291X(79)90235-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Forty-five amino acids at the amino terminus of macromomycin, a protein antitumor antibiotic, have the following sequence: Ala-Pro-Gly-Val-Thr-Val-Thr-Pro-Ala-Thr-Gly-Leu-Ser- Asn-Gly-Glu-Thr-Val-Thr-Val-Ser-Ala-Thr-Gly-Leu-Thr- Pro-Gly-Thr-Val-Tyr-His-Gly-Glu-Ser-Ala-Val-Ala-Glu- Pro-Gly-Val-Ile-Gly-Pro- ..... Of the first 31 residues in this sequence 16 are homologous with the amino terminal sequence in neocarzinostatin, a protein antitumor antibiotic which also degrades DNA. Because of this conservation of structure, this region of the molecule may be involved in the mechanism of action of these proteins. © 1979.

引用

页码：1133 / 1138

页数：6

共 17 条

[1] PROCESSING OF ADENOVIRUS 2-INDUCED PROTEINS [J].