DRUG RESISTANCE OF STAPHYLOCOCCI .16. INDUCTION OF CHLORAMPHENICOL RESISTANCE BY ITS DERIVATIVES AND ANALOGUES

Antibacterial activity of 16 chloramphenicol derivatives and their induction ability for chloramphenicol resistance were examined. Three chloramphenicol derivatives; CM 16 (DL-α-dichloroacetamido-β-bromo-p-nitropropiophenone), CM17 (DL-α-dichloroacetamido-β-methylene-p-nitropropiophenone) and CM18 (DL-α-acetamido-α-methylene-p-nitro-propiophenone) were found to be highly active against S-1477 but their inducible activity for chloramphenicol resistance was rather low. CM 26 (chloramphenicol monophosphate) and CM 29 (p-threo- 2,2-diethyl-5-dichloroacetamido-6-(p-nitrophenyl)-1,3-dioxane) has no antibacterial activity and CM 15 (DL-threo-2-dichloromethyl-4-p>-nitrophenyl-hydroxymethyl- Δ2-oxazoline) has very low activity against S-1477, but they have low inducible activity for chloramphenicol resistance in spite of no activity of other derivatives. © 1969, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.