ACROMEGALY IN 14 CATS

被引：127

作者：

PETERSON, ME

TAYLOR, RS

GRECO, DS

NELSON, RW

RANDOLPH, JF

FOODMAN, MS

MOROFF, SD

MORRISON, SA

LOTHROP, CD

机构：

[1] Departments of Medicine, Cornell University Medical College, New York, New York

[2] Departments of Pathology, The Animal Medical Center, Cornell University Medical College, New York, New York

[3] Research Animal Resource Center, Cornell University Medical College, New York, New York

[4] Lexington Blvd. Animal Hospital, Sugarland, Texas

[5] Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, Texas

[6] School of Veterinary Medicine, Purdue University, West Lafayette, Indiana

[7] Department of Clinical Sciences, New York State College of Veterinary Medicine, Cornell University, Ithaca, New York

[8] Veterinary Hospital, University of Pennsylvania, Philadelphia, Pennsylvania

[9] Department of Environmental Practice, University of Tennessee, College of Veterinary Medicine, Knoxville, Tennessee

来源：

JOURNAL OF VETERINARY INTERNAL MEDICINE | 1990年 / 4卷 / 04期

关键词：

D O I：

10.1111/j.1939-1676.1990.tb00897.x

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Acromegaly was diagnosed in 14 middle‐aged to old cats of mixed breeding. Thirteen (93%) of the cats were male and one was female. The earliest clinical signs in the 14 cats included polyuria, polydipsia, polyphagia, all of which were associated with untreated diabetes mellitus. All developed severe insulin resistance within a few months; peak insulin dosages required to control severe hyperglycemia ranged from 20 to 130 U per day. Other clinical findings weeks to months after diagnosis included enlargement of one or more organs (e.g., liver, heart, kidneys, and tongue) (n = 14), cardiomyopathy (n = 13), increase in body size and weight gain (n = 8), nephropathy associated with azotemia and clinical signs of renal failure (n = 7), degenerative arthropathy (n = 6), and central nervous system signs (i.e., circling and seizures) caused by enlargement of the pituitary tumor (n = 2). The diagnosis of acromegaly was confirmed by demonstration of extremely high basal serum growth hormone concentrations (22 to 131 μg/1) in all cats. Computerized tomography disclosed a mass in the region of the pituitary gland and hypothalamus in five of the six cats in which it was performed. Two cats were treated by cobalt radiotherapy followed by administration of a somatostatin analogue (octreotide), whereas two cats were treated with octreotide alone. Treatment had little to no effect in decreasing serum GH concentrations in any of the cats. Eleven of the 14 cats were euthanized or died four to 42 months (median survival time, 20.5 months) after the onset of acromegaly because of renal failure (n = 2), congestive heart failure (n = 1), concomitant renal failure and congestive heart failure (n = 3), progressive neurologic signs (n = 2), persistent anorexia and lethargy of unknown cause (n ‐ 1), the owner's unwillingness to treat the diabetes mellitus (n = 1), or unknown causes (n = 1). Results of necropsy examination in ten cats revealed a large pituitary acidophil adenoma (n = 10), marked left ventricular and septal hypertrophy (n = 7), dilated cardiomyopathy (n = 1), arthropathy affecting the shoulder, elbow, or stifle (n = 5), and glomerulopathy characterized by expansion of the mesangial matrix and variable periglomerular fi‐brosis (n = 10). (Journal of Veterinary Internal Medicine 1990; 4:192–201) Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：192 / 201

页数：10

共 49 条

[1] Gordon DA, Hill FM, Ezrin C., Acromegaly: A review of 100 cases, Can Med Assoc J, 87, pp. 1106-1109, (1962)
[2] Jadresic A., Banks LM, Child DF, Et al., The acromegaly syndrome: Relationship between clinical features, growth hormone values and radiological characteristics of the pituitary tumours, Q J Med, 202, pp. 189-204, (1982)
[3] Nabarro JD., Acromegaly, Clin Endocrinol (Oxf), 26, pp. 481-512, (1987)
[4] Acromegaly, Endocrinol Metab Clin North Am, 16, pp. 685-703, (1987)
[5] Gembardt C., Loppnow H., Zur pathogenese des spontanen dia‐betes mellitus der katze. II. Mitteilung: Azidophile adenome des hypophysenvorderlappens and diabetes mellitus in zwei fällen, Berl Munch Tieräztl Wschr, 89, pp. 336-340, (1976)
[6] Peterson ME, Javanovic L., Peterson CM, (1981)
[7] Eigenmann JE, Wortman JA, Haskins ME, Elevated growth hor‐mone levels and diabetes mellitus in a cat with acromegalic features, J Am Anim Hosp Assoc, 20, pp. 747-752, (1984)
[8] Lichtensteiger CA, Wortman JA, Eigenmann JE, Functional pitu‐itary acidophil adenoma in a cat with diabetes mellitus and acromegalic features, Vet Pathol, 23, pp. 518-521, (1986)
[9] Morrison SA, Randolph J., Lothrop CD, Hypersomatotropism and insulin‐resistant diabetes mellitus in a cat, J Am Vet Med Assoc, 194, pp. 91-94, (1989)
[10] Lothrop CD, Coulson PA, Nolan HL, Et al., Cyclic hormonogen‐esis in gray collie dogs: Interactions of hematopoietic and endocrine systems, Endocrinology, 120, pp. 1027-1032, (1987)

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