RANDOM CILIARY ORIENTATION - A CAUSE OF RESPIRATORY-TRACT DISEASE

被引:78
作者
RUTLAND, J
DEIONGH, RU
机构
[1] Respiratory Unit, Concord Hospital, Concord, Sydney
关键词
D O I
10.1056/NEJM199012133232406
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The clinical manifestations of primary ciliary dyskinesia (PCD) — recurrent sinopulmonary infection and male sterility — have been attributed to defects in the ultrastructure of the central core (axoneme) of cilia and sperm tails. In the respiratory tract, these structural defects impair ciliary motility and coordination, resulting in reduced mucociliary clearance. Defective ciliary function and structure were first reported as a cause of recurrent respiratory disease by Afzelius and coworkers,1 , 2 who noted decreased ciliary motility in patients with Kartagener's syndrome and suggested the term immotile-cilia syndrome. Subsequent studies of ciliary motility and ultrastructure have revealed a range of patterns of. © 1990, Massachusetts Medical Society. All rights reserved.
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页码:1681 / 1684
页数:4
相关论文
共 18 条
[1]   THE ORIENTATION OF CILIARY BASAL BODIES IN QUAIL OVIDUCT IS RELATED TO THE CILIARY BEATING CYCLE COMMENCEMENT [J].
BOISVIEUXULRICH, E ;
LAINE, MC ;
SANDOZ, D .
BIOLOGY OF THE CELL, 1985, 55 (1-2) :147-150
[2]   ORIENTATION OF RESPIRATORY-TRACT CILIA IN PATIENTS WITH PRIMARY CILIARY DYSKINESIA, BRONCHIECTASIS, AND IN NORMAL SUBJECTS [J].
DEIONGH, R ;
RUTLAND, J .
JOURNAL OF CLINICAL PATHOLOGY, 1989, 42 (06) :613-619
[3]   IMMOTILE-CILIA SYNDROME - CONGENITAL CILIARY ABNORMALITY AS AN ETIOLOGIC FACTOR IN CHRONIC AIRWAY INFECTIONS AND MALE-STERILITY [J].
ELIASSON, R ;
MOSSBERG, B ;
CAMNER, P ;
AFZELIUS, BA .
NEW ENGLAND JOURNAL OF MEDICINE, 1977, 297 (01) :1-6
[4]  
FZELIUS BA, 1976, SCIENCE, V183, P317
[5]   INVIVO CILIOGENESIS IN HUMAN-FETAL TRACHEAL EPITHELIUM [J].
GAILLARD, DA ;
LALLEMENT, AV ;
PETIT, AF ;
PUCHELLE, ES .
AMERICAN JOURNAL OF ANATOMY, 1989, 185 (04) :415-428
[6]   CILIARY DYSKINESIA WITH NORMAL ULTRASTRUCTURE [J].
GREENSTONE, MA ;
DEWAR, A ;
COLE, PJ .
THORAX, 1983, 38 (11) :875-876
[7]  
HERZON FS, 1980, ANN OTO RHINOL LARYN, V89, P881
[8]   KARTAGENERS SYNDROME WITH MOTILE SPERMATOZOA [J].
JONSSON, MS ;
MCCORMICK, JR ;
GILLIES, CG ;
GONDOS, B .
NEW ENGLAND JOURNAL OF MEDICINE, 1982, 307 (18) :1131-1133
[9]  
MOREAU MF, 1985, ACTA CYTOL, V29, P248
[10]  
NIELSEN MH, 1983, EUR J RESPIR DIS S, V127, P19