ASYMMETRIC CATALYSIS .65. ENANTIOSELECTIVE ALKYLATION OF ALPHA-ISOPROPYL-3,4-DIMETHOXYBENZYLCYANIDE

被引：15

作者：

BRUNNER, H

ZINTL, H

机构：

来源：

MONATSHEFTE FUR CHEMIE | 1991年 / 122卷 / 10期

关键词：

MICHAEL REACTION; ALLYLATION; ENANTIOSELECTIVITY; PD-CATALYSIS;

D O I：

10.1007/BF00815922

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The base-catalyzed Michael reaction and the palladium-catalyzed allylation were used to build up the quaternary asymmetric center of the Verapamil skeleton by enantioselective alkylation of alpha-isopropyl-3,4-dimethoxybenzylcyanide. Optical inductions up to 10.5% ee were achieved.

引用

页码：841 / 848

页数：8

共 17 条

[1]

BLASCHKE G, 1979, ARZNEIMITTEL-FORSCH, V29-2, P1640

[2]

BRUNNER H, 1988, SYNTHESIS-STUTTGART, P645

[3] ENANTIOSELECTIVE CATALYSIS .62. 1,2-BIS(DIMETHYLPHOSPHINO)ETHANE [J].